Evidence for an interaction between apolipoprotein E genotype, gender, and Alzheimer disease
Evidence for an interaction between apolipoprotein E genotype, gender, and Alzheimer disease
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DOI：
10.1097/00002093-199910000-00007
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发表时间：
1999-10-01
影响因子：
2.1
通讯作者：
Henderson, VW
中科院分区：
文献类型：
--
作者：
Bretsky, PM;Buckwalter, JG;Henderson, VW
载脂蛋白E（APOE）EPSILON 4等位基因的载体显示出明显更高的阿尔茨海默氏病风险（AD）。本研究的目的是检验以下假设：APOE基因型和性别之间存在显着相互作用。性别的Epsilon 4相互作用，尽管在文献中指示，但需要进一步验证。在正在进行的对衰老和痴呆症的纵向研究中，共有195个过去或当前的控制或AD参与者。所有受试者都至少60岁。痴呆受试者符合晚发性AD的临床或病理标准。逻辑回归分析和比例危害模型用于评估APOE和性别的关节效应。在逻辑回归分析中，显示了APOE和性别之间的显着统计相互作用（P = 0.04）。携带一个或多个apoe-epsilon 4等位基因的妇女更有可能发展AD [优势比（OR）= 7.8，95％置信区间（CI）= 3.2-19.1]。对于男性，Apoe-Epsilon 4等位基因的存在与统计学上显着的风险增加无关（OR = 1.6，95％CI = 0.5-5.3）。比例危害模型中的相互作用项接近（p = 0.07）统计显着性，并且显示了类似但减少的性别效应。分析表明，一个或多个apoe-epsilon 4等位基因的存在赋予女性的AD风险大大比男性更大。这些发现部分可能解释了妇女面临的广告风险增加的报道。
Carriers of the apolipoprotein E (APOE) epsilon 4 allele show significantly higher risk of Alzheimer disease (AD). The aim of this present study was to test the hypothesis that a significant interaction exists between APOE genotype and gender on AD. Interactions of epsilon 4 by gender, although indicated in the literature, require further verification. A total of 195 past or current control or AD participants in an ongoing longitudinal study of aging and dementia were genotyped. All subjects were at least 60 years old; demented subjects met clinical or pathologic criteria for late-onset AD. Logistic regression analysis and proportional hazard models were used to evaluate joint effects of APOE and gender. A significant statistical interaction between APOE and gender was shown (p = 0.04) in logistic regression analysis. Women carrying one or more APOE-epsilon 4 allele were more likely to develop AD [odds ratio (OR) = 7.8, 95% confidence interval (CI) = 3.2-19.1]. For men, the presence of the APOE-epsilon 4 allele was not associated with a statistically significant increased risk (OR = 1.6, 95% CI = 0.5-5.3). The interaction term in the proportional hazards model neared (p = 0.07) statistical significance, and a similar but reduced gender effect was shown. The analysis suggests that the presence of one or more APOE-epsilon 4 allele confers a substantially greater risk of AD to women than to men. These findings in part may account for reports of increased risk of AD faced by women.