Emotion Regulation Abnormalities in Schizophrenia: Cognitive Change Strategies Fail to Decrease the Neural Response to Unpleasant Stimuli
Emotion Regulation Abnormalities in Schizophrenia: Cognitive Change Strategies Fail to Decrease the Neural Response to Unpleasant Stimuli
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DOI：
10.1093/schbul/sbs186
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发表时间：
2013-07-01
影响因子：
6.6
通讯作者：
Gold, James M.
中科院分区：
文献类型：
--
作者：
Strauss, Gregory P.;Kappenman, Emily S.;Gold, James M.
与早期对精神分裂症（SZ）情绪体验的概念相反，最近的研究表明，患者并不比对照组（CN）自我报告的瞬间快乐少。相反，患者报告说，在一系列唤起刺激的反应中，他们经历了高水平的负面情绪。在这项研究中，我们研究的可能性，在SZ的负情绪的海拔可能反映了一个潜在的情绪调节异常。事件相关电位（ERP）记录从SZ门诊患者（n = 25）和人口统计学匹配的健康对照组（n = 21）在被动观看不愉快和中性照片。令人不快的图像之前有一个音频描述，描述图像是负面的或中性的。中性的图像之前是中性的音频描述。研究了对认知改变策略敏感的ERP成分--晚期正电位（LPP）作为情绪调节的指标。与中性图像相比，CN和SZ都显示出对负面描述的不愉快图像的LPP增加。此外，CN表现出情绪调节的证据，反映了一个较小的LPP不愉快的图像之前的中性描述符，相对于一个负面的描述符。相比之下，SZ患者表现出无法下调情绪反应，证明了不愉快的图像之前的负面或中性的描述符的LPP的幅度没有差异。研究结果提供了神经生理学证据的情绪调节异常，在深圳，并建议在认知变化的失败可能会增加在深圳的负面情绪。
Contrary to early conceptualizations of emotional experience in schizophrenia (SZ), recent research indicates that patients do not self-report less in-the-moment pleasure than controls (CN). Rather, patients report experiencing elevated levels of negative emotionality in response to a range of evocative stimuli. In this study, we examined the possibility that elevations in negative emotionality in SZ may reflect an underlying emotion regulation abnormality. Event-related potentials (ERPs) were recorded from outpatients with SZ (n = 25) and demographically matched healthy controls (n = 21) during passive viewing of unpleasant and neutral photographs. Unpleasant images were preceded by an audio description that described the image as being either negative or neutral. Neutral images were preceded by neutral audio descriptions. The late positive potential (LPP), an ERP component sensitive to cognitive change strategies, was examined as an index of emotion regulation. Both CN and SZ showed an increased LPP to negatively described unpleasant images compared with neutral images. In addition, CN showed evidence of emotion regulation, as reflected by a smaller LPP for unpleasant images preceded by a neutral descriptor, relative to a negative descriptor. In contrast, SZ patients showed an inability to downregulate emotional response, as evidenced by no difference in the amplitude of the LPP for unpleasant images preceded by negative or neutral descriptors. Findings provide neurophysiological evidence for an emotion regulation abnormality in SZ and suggest that failures in cognitive change may underlie increased negative emotionality in SZ.