Relationship of ALDH2 rs671 and CYP2E1 rs2031920 with hepatocellular carcinoma susceptibility in East Asians: a meta-analysis
Relationship of ALDH2 rs671 and CYP2E1 rs2031920 with hepatocellular carcinoma susceptibility in East Asians: a meta-analysis
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DOI：
10.1186/s12957-020-1796-0
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发表时间：
2020-01-27
影响因子：
3.2
通讯作者：
Liu, Kai
中科院分区：
文献类型：
--
作者：
Chen, Junhong;Pan, Weicong;Liu, Kai
醛脱氢酶2 （ALDH2）和细胞色素p450 2E1 （CYP2E1）是重要的酒精代谢酶。本荟萃分析的目的是评估东亚人ALDH2 rs671和CYP2E1 rs2031920多态性与肝细胞癌（HCC）易感性的关系。方法对MEDLINE、PubMed、Scopus、Embase和中国学术期刊数据库进行系统检索。19项病例对照研究入选。通过随机效应或固定效应模型计算合并优势比（ORs）和95%置信区间（ci）。进行亚组分析、meta回归、敏感性分析、累积meta分析和发表偏倚评价。结果整体荟萃分析未发现ALDH2 rs671和CYP2E1 rs2031920基因型与东亚人的HCC易感性有显著关联。此外，按国家、Hardy-Weinberg平衡状态和对照来源进行的分层分析也未发现任何关联。结论ALDH2 rs671和CYP2E1 rs2031920基因多态性与东亚人的HCC易感性无关。
Background Aldehyde dehydrogenase 2 (ALDH2) and cytochrome p450 2E1 (CYP2E1) are important alcohol-metabolizing enzymes. The aim of this meta-analysis was to evaluate the association of ALDH2 rs671 and CYP2E1 rs2031920 polymorphisms with hepatocellular carcinoma (HCC) susceptibility in East Asians. Methods A systematic search strategy was implemented in MEDLINE, PubMed, Scopus, Embase, and China Academic Journals databases. Nineteen case-control studies were selected for inclusion. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated through random-effects or fixed-effects models. Subgroup analysis, meta-regression, sensitivity analysis, cumulative meta-analysis, and evaluation of publication bias were performed. Results The overall meta-analysis did not find a significant association of ALDH2 rs671 and CYP2E1 rs2031920 genotypes with HCC susceptibility in East Asians. In addition, stratified analysis by country, Hardy-Weinberg equilibrium status, and source of controls also did not identify any association. Conclusion The ALDH2 rs671 and CYP2E1 rs2031920 polymorphisms are not associated with HCC susceptibility in East Asians.