Administration of oxaliplatin to a pregnant woman with rectal cancer
Administration of oxaliplatin to a pregnant woman with rectal cancer
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患有直肠癌的孕妇服用奥沙利铂
DOI：
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发表时间：
2008
影响因子：
3
通讯作者：
A. Craig Lockhart
中科院分区：
文献类型：
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作者：
M. Gensheimer;Catherine A. Jones;Cornelia R. Graves;N. Merchant;A. Craig Lockhart
Purpose铂剂奥沙利铂可以是有用的治疗癌症的孕妇，但它是胎儿毒性的大鼠和其对人类胎儿的影响是unknown.MethodsOxaliplatin管理到一个25岁的孕妇与转移性直肠癌从20至30周的孕龄作为mFOLFOX-6 regimeneration.ResultsThe患者生下了一个健康的女孩在33周的孕龄。在后续行动中，3岁的孩子已经实现了所有适当的生长和发育milestones.DiscussionOxaliplatin是几个现代化疗方案的组成部分。本报告证明了奥沙利铂在妊娠中期和妊娠晚期给药无明显的胎儿损害。
PurposeThe platinum agent oxaliplatin could be useful in treatment of cancer in pregnant women, but it is fetotoxic in rats and its effect on the human fetus is unknown.MethodsOxaliplatin was administered to a 25-year-old pregnant woman with metastatic rectal cancer from 20 to 30 weeks gestational age as part of the mFOLFOX-6 regimen.ResultsThe patient gave birth to a healthy girl at 33 weeks gestational age. At follow-up, the 3-year-old child had achieved all appropriate growth and developmental milestones.DiscussionOxaliplatin is a component of several modern chemotherapy regimens. This report demonstrates the administration of oxaliplatin in the second and third trimesters of pregnancy without apparent fetal harm.