Creation of a standardized geometry of the human nasal cavity
Creation of a standardized geometry of the human nasal cavity
复制标题
DOI：
10.1152/japplphysiol.90376.2008
复制
发表时间：
2009-03-01
影响因子：
3.3
通讯作者：
Marsan, J.
中科院分区：
文献类型：
--
作者：
Liu, Y.;Johnson, M. R.;Marsan, J.
Liu Y，约翰逊MR，Matida EA，Kherani S，Marsan J.人类鼻腔标准化几何形状的创建。J Appl Physiol 106：784-795，2009.首次发表于2009年1月8日; doi：10.1152/japplphysiol. 90376.2008.-通过对齐和处理健康受试者鼻气道的30组计算机断层扫描（CT）扫描，创建了一种新的标准化人体鼻腔几何形状。从CT扫描中生成60个单个人类鼻腔（30个右侧和30个镜像左侧腔）的数字三维（3-D）几何形状，并测量每个单个鼻腔的物理参数。开发了一种方法来缩放、定向和对齐鼻部几何形状，然后生成2-D数字冠状截面切片。通过使用创新的图像处理算法，创建了中值横截面几何形状，以匹配中值物理参数，同时保留了人类鼻腔的独特几何特征。从这些理想化的2-D图像中，创建了原始的3-D标准化的正中人类鼻腔。将这种新的标准化几何结构与所有受试者的原始几何结构以及文献中有限的现有数据进行比较。新的模型有可能作为几何标准，在未来的实验和数值研究的沉积吸入气溶胶，以及作为一个参考，在诊断不健康的病人。开发的特定程序也可以应用于为较大人群中的不同可识别群体构建标准鼻几何形状。
Liu Y, Johnson MR, Matida EA, Kherani S, Marsan J. Creation of a standardized geometry of the human nasal cavity. J Appl Physiol 106: 784-795, 2009. First published January 8, 2009; doi:10.1152/japplphysiol. 90376.2008.-A novel, standardized geometry of the human nasal cavity was created by aligning and processing 30 sets of computed tomography (CT) scans of nasal airways of healthy subjects. Digital three-dimensional (3-D) geometries of the 60 single human nasal cavities (30 right and 30 mirrored left cavities) were generated from the CT scans and measurements of physical parameters of each single nasal cavity were performed. A methodology was developed to scale, orient, and align the nasal geometries, after which 2-D digital coronal cross-sectional slices were generated. With the use of an innovative image processing algorithm, median cross-sectional geometries were created to match median physical parameters while retaining the unique geometric features of the human nasal cavity. From these idealized 2-D images, an original 3-D standardized median human nasal cavity was created. This new standardized geometry was compared against the original geometries of all subjects as well as limited existing data from the literature. The new model has potential for use as a geometric standard in future experimental and numerical studies of deposition of inhaled aerosols, as well as for use as a reference during diagnosis of unhealthy patients. The specific procedure developed could also be applied to build standard nasal geometries for different identifiable groups within the larger population.