Upregulated circZMIZ1 promotes the proliferation of prostate cancer cells and is a valuable marker in plasma
Upregulated circZMIZ1 promotes the proliferation of prostate cancer cells and is a valuable marker in plasma
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DOI：
10.4149/neo_2019_190213n116
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发表时间：
2020-01-01
期刊：
影响因子：
3
通讯作者：
Zhao, S. C.
中科院分区：
文献类型：
--
作者：
Jiang, H.;Lv, D. J.;Zhao, S. C.
越来越多的证据证明，环状RNA（circRNA）作为一种特殊的非编码RNA，在包括前列腺癌在内的肿瘤发生中发挥着潜在的关键作用。然而，circRNA 在人类前列腺癌中的功能仍然很大程度上未知。在这项研究中，我们证明了circZMIZ1在人前列腺癌血浆中的表达高于配对良性前列腺增生(BPH)患者血浆中的表达。此外，在培养的前列腺癌细胞中，敲低 circZMIZ1 会抑制细胞增殖并导致细胞周期停滞在 G1 期。从机制上讲，我们还发现circZMIZ1可以增加雄激素受体（AR）和雄激素受体剪接变体7（AR-V7）的表达，这可能在一定程度上促进了前列腺癌的发生和发展。总之，这些结果表明 circZMIZ1 可能作为前列腺癌治疗的新型生物标志物和治疗靶点。
Increasing evidences have proved that circular RNAs (circRNAs), identified as a specific kind of non-coding RNAs, play a potential critical role in tumorigenesis including prostate cancer. However, the function of circRNAs in human prostate cancer remains largely unknown. In this study, we demonstrated that the expression of circZMIZl was higher in plasma of human prostate cancer than the paired benign prostatic hyperplasia (BPH) patients' plasma. Moreover, in cultured prostate cancer cells, knockdown of circZMIZ1 inhibited cell proliferation and caused cell cycle arrest at G1. Mechanistically, we also showed that circZMIZ1 could increase the expression of androgen receptor (AR) and androgen receptor splice variant 7 (AR-V7), which may be partly contributed to the occurrence and development of prostate cancer. In conclusion, these results revealed that circZMIZ1 might serve as a novel biomarker and a treatment target for prostate cancer treatment.