Postprandial cholecystokinin release and gastric emptying in patients with bulimia nervosa
Postprandial cholecystokinin release and gastric emptying in patients with bulimia nervosa
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DOI：
10.1093/ajcn/65.1.114
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发表时间：
1997-01-01
影响因子：
7.1
通讯作者：
Petkova, E
中科院分区：
文献类型：
--
作者：
Devlin, MJ;Walsh, BT;Petkova, E
这项研究旨在调查神经性暴食症患者饱腹感缺陷的生物学基础。8名患有神经性暴食症的女性和10名年龄和体重匹配的对照组受试者吃了三顿实验室餐，包括200克、400克和600克放射性标记液体餐。每餐后1h，每隔10min采集血样测定胆囊收缩素浓度，并测量胃排空。受试者还每隔10分钟完成一次知觉评分表。与对照组相比，神经性贪食症患者表现出餐后胆囊收缩素释放迟钝，特别是在进餐较多的情况下，以及胃排空延迟。患者暴饮暴食的欲望增加与进餐数量增加有关，而对照组则没有。这些数据支持一种模型，即胃容量增加，可能是由于反复暴饮暴食，导致胃排空延迟，餐后胆囊收缩素释放迟钝，导致饱腹感反应受损，这往往会使疾病持续下去。
This study was designed to investigate the biological underpinnings of the observed deficit in satiety in patients with bulimia nervosa. Eight women with bulimia nervosa and 10 age- and weight-matched control subjects consumed three laboratory meals consisting of 200, 400, and 600 g of a radiolabeled liquid meal. For 1 h after each meal, blood samples were obtained at 10-min intervals for measurement of cholecystokinin concentration and gastric emptying was measured. Subjects also completed perceptual rating scales at 10-min intervals. Compared with control subjects, patients with bulimia nervosa showed a blunting of postprandial cholecystokinin release, particularly with larger meal sizes, as well as delayed gastric emptying. Increasing meal size was associated with increased desire to binge eat in patients but not in control subjects. These data lend support to a model in which increased gastric capacity, perhaps resulting from replated binge eating, gives rise to delayed gastric emptying and blunted postprandial cholecystokinin release, leading to an impaired satiety response, which tends to perpetuate the illness.