Adjunctive effect of antimicrobial photodynamic therapy to nonsurgical periodontal treatment in smokers: a randomized clinical trial
Adjunctive effect of antimicrobial photodynamic therapy to nonsurgical periodontal treatment in smokers: a randomized clinical trial
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DOI：
10.1007/s10103-013-1379-1
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发表时间：
2015-02-01
影响因子：
2.1
通讯作者：
Souza, Sergio L. S.
中科院分区：
文献类型：
--
作者：
Queiroz, Adriana C.;Suaid, Flavia Adelino;Souza, Sergio L. S.
本研究的目的是探讨抗菌光动力疗法（aPDT）对慢性牙周炎吸烟者的刮治和根刨（SRP）的辅助作用。20例受试者有2个对侧牙齿，随机分配接受SRP （SRP组）或SRP +单次aPDT （SRP + aPDT组），使用二极管激光和吩噻嗪光敏剂。记录牙菌斑指数、探诊出血、探诊深度（PD）、临床附着水平（CAL）、牙龈退行情况，采集龈沟液检测IL-1 β和基质金属蛋白酶(MMP)-8水平。两组PD均显著降低（SRP 1.81 +/- 0.52 mm/SRP + aPDT 1.58 +/- 1.28 mm, p < 0.001）， CAL显著增加（SRP 1.60 +/- 0.92 mm/SRP + aPDT 1.41 +/- 1.58 mm, p < 0.001）。组间比较无显著差异。SRP组龈沟液IL-1 β水平在1周后升高（SRP为24.65 +/- 18.85 pg/mu L/SRP + aPDT为34.07 +/- 24.81 pg/mu L, p = 0.048）， MMP-8水平在12周后升高（SRP为303.31 +/- 331.62 pg/mu L/SRP + aPDT为534.23 +/- 647.37 pg/mu L, p = 0.024）。组内比较差异无统计学意义。aPDT的辅助作用不能保证改善吸烟者的临床参数。然而，与单独使用SRP相比，它导致IL-1 β和MMP-8的抑制。
The aim of this study was to investigate the adjunctive effect of antimicrobial photodynamic therapy (aPDT) to scaling and root planing (SRP) in smokers with chronic periodontitis. Twenty subjects had two contralateral teeth randomly assigned to receive SRP (SRP group) or SRP + a single episode of aPDT (SRP + aPDT group), with a diode laser and a phenothiazine photosensitizer. Plaque index, bleeding on probing, probing depth (PD), clinical attachment level (CAL), and gingival recession were recorded, and gingival crevicular fluid was collected for assay of IL-1 beta and matrix metalloproteinase (MMP)-8 levels. There was a significant PD reduction (SRP 1.81 +/- 0.52 mm/SRP + aPDT 1.58 +/- 1.28 mm; p < 0.001) and a significant CAL gain (SRP 1.60 +/- 0.92 mm/SRP + aPDT 1.41 +/- 1.58 mm; p < 0.001) for both groups. Significant differences were not observed in between-group comparisons. IL-1 beta level in gingival crevicular fluid was higher in SRP group after 1 week (SRP 24.65 +/- 18.85 pg/mu L/SRP + aPDT 34.07 +/- 24.81 pg/mu L; p = 0.048), and MMP-8 level was higher in SRP group after 12 weeks (SRP 303.31 +/- 331.62 pg/mu L/SRP + aPDT 534.23 +/- 647.37 pg/mu L; p = 0.024). There were no statistically significant differences in intragroup comparisons. The adjunctive effect of aPDT did not warrant improvements on clinical parameters in smokers. However, it resulted in a suppression of IL-1 beta and MMP-8 when compared with SRP alone.