Biological component of the NIMH clinical research branch collaborative program on the psychobiology of depression: I. Background and theoretical considerations.
Biological component of the NIMH clinical research branch collaborative program on the psychobiology of depression: I. Background and theoretical considerations.
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NIMH 抑郁症心理生物学临床研究分支合作项目的生物学组成部分：I. 背景和理论考虑。
DOI：
10.1017/s0033291700055057
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发表时间：
1980
影响因子：
6.9
通讯作者：
Bowden,CL
中科院分区：
文献类型：
--
作者：
Maas,JW;Koslow,SH;Davis,JM;Katz,MM;Mendels,J;Robins,E;Stokes,PE;Bowden,CL
有许多报告表明，情感性疾病（躁狂症和/或抑郁症）患者的一个或多个神经生物学系统的功能异常。在一次由临床研究分支召开的会议上，校外研究计划，国家精神卫生研究所，这些研究结果进行了审查，并确定了一些因素阻碍运动走向更完整和综合的观点，神经生物学系统的功能，躁狂症或抑郁症患者。因此，一个多研究中心，协作的方法来研究情感障碍的心理生物学的发展。这一合作方案已进行了几年，其重点是：（a）在治疗前和治疗期间评估同一病人体内几种不同类型生物系统的功能;（B）获得相当多的病人和比较对象;（c）在各中心内部和之间使用标准化诊断类别和行为评级方法。在本文中，历史，背景和理由，这一合作的努力进行审查。这些生物系统选择的研究，并指出，如诊断的可靠性和有效性，状态变量的测量，评估与治疗的变化，以及后勤和协调问题进行了讨论。
There are many reports which suggest that patients with affective illness (mania and/or depression) have abnormalities in the functioning of one or more neurobiological systems. At a conference convened by the Clinical Research Branch, Division of Extramural Research Programs, National Institute of Mental Health, these findings were reviewed and some of the factors impeding movement towards a more complete and integrated view of the functioning of neurobiological systems in patients with mania or depression were identified. As a result, a multi-research centre, collaborative approach to the study of the psychobiology of affective disorders was developed. In this collaborative programme, which has now been underway for several years, the focus has been upon: (a) the assessment of the functioning of several different types of biological systems in the same patient, both before and during treatment; (b) obtaining a reasonably large number of patients and comparison subjects; and (c) the use within and across centres of standardized diagnostic categories and behavioural rating methodologies. In this paper the history, background, and rationale for this collaborative effort are reviewed. Those biological systems chosen for study are noted, and issues such as reliability and validity of diagnoses, measurement of state variables, assessment of change with treatment, and logistical and coordinating problems are discussed.