Direct Asymmetric anti-Mannich-Type Reactions Catalyzed by Cinchona Alkaloid Derivatives
Direct Asymmetric anti-Mannich-Type Reactions Catalyzed by Cinchona Alkaloid Derivatives
复制标题
DOI：
10.1002/chir.22358
复制
发表时间：
2014-12-01
期刊：
影响因子：
2
通讯作者：
Zhang, Xiu Rong
中科院分区：
文献类型：
--
作者：
Jin, Ying;Chen, Di;Zhang, Xiu Rong
利用一系列金鸡纳生物碱衍生物催化了3-甲基-2-氧吲哚与n -甲酰基醛胺的不对称反曼尼奇型反应。所得的抗3,3-二取代2-氧吲哚产物收率高（达92%），非映对映选择性高（抗/syn达97:3，ee达91%）。手性学报（自然科学版），2014。(c) 2014 Wiley期刊公司
A series of cinchona alkaloid derivatives were used to catalyze the asymmetric anti-Mannich-type reaction of 3-methyl-2-oxindole with N-tosyl aryl aldimines. The resulting anti-3,3-disubstituted 2-oxindole products were obtained in good yields (up to 92%) with high diastereo- and enantioselectivities (anti/syn up to 97:3 and 91% ee). Chirality 26:801-805, 2014. (c) 2014 Wiley Periodicals, Inc.