Sources of variation of transthyretin in healthy subjects in East and Southeast Asia: Clinical and experimental evidence for the effect of alcohol on transthyretin metabolism.
Sources of variation of transthyretin in healthy subjects in East and Southeast Asia: Clinical and experimental evidence for the effect of alcohol on transthyretin metabolism.
复制标题
东亚和东南亚健康受试者转甲状腺素蛋白变异的来源：酒精对转甲状腺素蛋白代谢影响的临床和实验证据。
DOI：
10.1016/j.cca.2016.04.011
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发表时间：
2016
期刊：
影响因子：
5
通讯作者：
Ando Y; Scientific Committee for the Asia-Pacific Federation of Clinical Biochemistry.
中科院分区：
文献类型：
--
作者：
Jono H;Su Y;Obayashi K;Tanaka Y;Ishiguro A;Nishimura H;Shinriki S;Ueda M;Ikeda K;Yamagata K;Ichihara K;Ando Y; Scientific Committee for the Asia-Pacific Federation of Clinical Biochemistry.
背景甲状腺素运载蛋白（transthyretin，TTR）是一种负性急性时相蛋白，虽然被公认为营养评估蛋白之一，但对健康受试者血清TTR浓度的影响因素比营养状况还不清楚。我们调查的来源，血清TTR浓度的变化在健康subjects.MethodsSerum样本3511例健康志愿者（2055日本人和1456其他东亚和东南亚的主题）收集。除常规血液检查外，我们还测量了每个样本的血清TTR浓度，并评估了每个血清TTR浓度与临床指标（如年龄、性别、体重指数（BMI）、吸烟和每日饮酒水平）之间的关系。我们还调查了TTR表达的直接酒精效应，通过评估TTR的mRNA和蛋白水平在vivoandin vitroexperiments.ResultsMean TTR浓度的男性显着高于女性。多元回归分析显示，血清TTR浓度随年龄、BMI和每日饮酒水平的增加而增加，调整了轻微的地区差异。结论性别、年龄、BMI、饮酒量可能是影响健康人血清TTR浓度的因素。
BackgroundAlthough transthyretin (TTR), a negative acute phase protein, is recognized as one of the nutrition assessment proteins, factors affecting serum TTR concentrations than nutritional state in healthy subjects have not been well understood. We investigated the sources of variation of serum TTR concentrations in healthy subjects.MethodsSerum samples of 3511 healthy volunteers (2055 of Japanese subjects and 1456 of other East and Southeast Asian subjects) were collected. We measured serum TTR concentrations in addition to routine blood examinations in each sample, and assessed the relationship between each serum TTR concentrations and the clinical indices such as age, sex, body mass index (BMI), smoking, and level of daily alcohol consumption. We also investigated the direct alcohol effect of TTR expression by assessing TTR mRNA and protein levelsin vivoandin vitroexperiments.ResultsMean TTR concentrations of males were prominently higher than those of females. Multiple regression analysis revealed that serum TTR concentrations increased with age, BMI, and the level of daily alcohol consumption after adjustment for a slight regional difference. Moreover, TTR expression was up-regulated by alcohol treatment through hepatocyte nuclear factor 4α (HNF-4α)in vitroandin vivoexperiments.ConclusionsSex, aging, BMI, and the level of daily alcohol consumption may be the factors affecting serum TTR concentrations in healthy subjects.