Association between serum cell adhesion molecules with hs-CRP, uric acid and VEGF genetic polymorphisms in subjects with metabolic syndrome
Association between serum cell adhesion molecules with hs-CRP, uric acid and VEGF genetic polymorphisms in subjects with metabolic syndrome
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DOI：
10.1007/s11033-019-05081-2
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发表时间：
2019-12-23
影响因子：
2.8
通讯作者：
Ghayour-Mobarhan, Majid
中科院分区：
文献类型：
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作者：
Ghazizadeh, Hamideh;Rezaei, Majid;Ghayour-Mobarhan, Majid
代谢综合征（MetS）与促炎状态和内皮功能障碍相关，这使MetS受试者处于动脉粥样硬化的较高风险。炎症性生物标志物在有患心血管疾病风险的患者中升高。本研究旨在探讨代谢综合征与血清可溶性粘附分子、高敏C反应蛋白（hs-CRP）、尿酸及血管内皮生长因子（VEGF）相关基因变异的关系。在这项横断面研究中，参与者来自马什哈德中风和心脏动脉粥样硬化疾病（MASHAD）研究。采用国际糖尿病联合会标准定义代谢综合征。分别采用ELISA法和PEG增强免疫比浊法检测细胞粘附分子（CAM）和血清hs-CRP。我们使用逻辑回归分析来确定CAM与VEGF多态性和MetS的独立关联。259名有和没有MetS的参与者被招募。代谢综合征和糖尿病患者血清E-选择素水平显著高于对照组（p < 0.05）。血清E-选择素水平高的受试者hs-CRP、FBG、TG、尿酸、BMI水平高，而血清HDL-C水平低（p < 0.05）。有趣的是，具有VEGF基因（rs6921438）的遗传变体的MetS个体具有更高的血清ICAM-1水平（p = 0.04）。血清E-选择素浓度与MetS及其危险因素之间存在显著相关性。此外，我们证明了具有rs6921438遗传变体的MetS受试者具有较高的血清ICAM-1水平（p < 0.05）。
Metabolic syndrome (MetS) is associated with a pro-inflammatory state and endothelial dysfunction that places subjects with MetS at a higher risk of atherosclerosis. Inflammatory biomarkers are raised in patients at risk of developing cardiovascular diseases. In the current study, we aimed to examine the possible association between MetS and serum soluble adhesion molecules, hs-CRP, uric acid, and the genetic variations related to vascular endothelial growth factor (VEGF) gene. In this cross-sectional study, participants were enrolled from the Mashhad stroke and heart atherosclerotic disorders (MASHAD) study. The International Diabetes Federation criteria were used to define the MetS. Cell adhesion molecules (CAM) and serum hs-CRP were measured by ELISA and PEG-enhanced immunoturbidimetry method, respectively. We used a logistic regression analysis to determine independent associations of CAMs with the VEGF polymorphisms and MetS. Two hundred and 59 participants with and without MetS were enrolled. Participants with MetS and DM had a significantly higher serum E-selectin level (p < 0.05). Participants with a high serum E-selectin level had higher levels of hs-CRP, FBG, TG, uric acid, BMI and lower levels of serum HDL-C (p < 0.05). Interestingly, individuals with MetS with a genetic variant of the VEGF gene (rs6921438) had higher level of serum ICAM-1 (p = 0.04). There were significant associations between serum E-selectin concentrations and the presence of MetS, and its risk factors. Moreover, we demonstrated that MetS subjects with the rs6921438 genetic variant had a higher serum level of ICAM-1 (p < 0.05).