Estimating oxygen consumption rates of arteriolar walls under physiological conditions in rat skeletal muscle
Estimating oxygen consumption rates of arteriolar walls under physiological conditions in rat skeletal muscle
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DOI：
10.1152/ajpheart.00830.2004
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发表时间：
2005-07-01
影响因子：
4.8
通讯作者：
Kamiya, A
中科院分区：
文献类型：
--
作者：
Shibata, M;Ichioka, S;Kamiya, A
To examine the effects of vascular tone reduction on O-2 consumption of the vascular wall, we determined the O-2 consumption rates of arteriolar walls under normal conditions and during vasodilation induced by topical application of papaverine. A phosphorescence quenching technique was used to quantify intra- and perivascular PO2 in rat cremaster arterioles with different branching orders. Then, the measured radial PO2 gradients and a theoretical model were used to estimate the O-2 consumption rates of the arteriolar walls. The vascular O-2 consumption rates of functional arterioles were > 100 times greater than those observed in in vitro experiments. The vascular O-2 consumption rate was highest in first-order (1A) arterioles, which are located upstream, and sequentially decreased downstream in 2A and 3A arterioles under normal conditions. During papaverine-induced vasodilation, on the other hand, the O-2 consumption rates of the vascular walls decreased to similar levels, suggesting that the high O-2 consumption rates of 1A arterioles under normal conditions depend in part on the workload of the vascular smooth muscle. These results strongly support the hypothesis that arteriolar walls consume a significant amount of O-2 compared with the surrounding tissue. Furthermore, the reduction of vascular tone of arteriolar walls may facilitate an efficient supply of O-2 to the surrounding tissue.
