THE LET-23 GENE NECESSARY FOR CAENORHABDITIS-ELEGANS VULVAR INDUCTION ENCODES A TYROSINE KINASE OF THE EGF RECEPTOR SUBFAMILY
THE LET-23 GENE NECESSARY FOR CAENORHABDITIS-ELEGANS VULVAR INDUCTION ENCODES A TYROSINE KINASE OF THE EGF RECEPTOR SUBFAMILY
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DOI：
10.1038/348693a0
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发表时间：
1990-12-20
期刊：
影响因子：
64.8
通讯作者：
STERNBERG, PW
中科院分区：
文献类型：
--
作者：
AROIAN, RV;KOGA, M;STERNBERG, PW
let-23基因是诱导秀丽隐杆线虫所必需的。结果表明let-23编码一个表皮生长因子受体亚家族的酪氨酸激酶。因此，let-23可能编码外阴发育所需的诱导信号的受体。由于let-23在外阴决定途径中作用于let-60 ras的上游，因此let-23产物的鉴定为细胞类型决定途径中酪氨酸激酶生长因子受体和ras蛋白之间的体内连接提供了支持。
Thelet-23gene is required for induction of theCaenorhabditis elegansvulva. It is shown thatlet-23encodes a putative tyrosine kinase of the epidermal growth factor receptor subfamily. Thus,let-23might encode the receptor for the inductive signal required for vulval development. Becauselet-23acts upstream oflet-60 rasin the vulval determination pathway, the identification of thelet-23product provides support for a linkin vivobetween tyrosine kinase growth factor receptors andrasproteins in a pathway of cell-type determination.