Effects of the perfluorochemical emulsion FMIQ on the radiation response of EMT6 tumours.
Effects of the perfluorochemical emulsion FMIQ on the radiation response of EMT6 tumours.
复制标题
全氟化合物乳液 FMIQ 对 EMT6 肿瘤放射反应的影响。
DOI：
10.1080/09553009214551711
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发表时间：
1992
影响因子：
2.6
通讯作者：
Irvin,CG
中科院分区：
文献类型：
--
作者：
Rockwell,S;Kelley,M;Irvin,CG
使用BALB/c小鼠和EMT 6乳腺癌检查了基于全氟-N-甲基十氢异喹啉的全氟化学乳剂FMIQ的效果。FMIQ的放射生物学效应与先前在相同肿瘤/宿主系统中发现的Fluosol®相似。虽然FMIQ的全氟化合物含量（20%w/v）和携氧能力与Fluosol相似，但FMIQ的配方比Fluosol具有一些优势。例如，FMIQ在储存期间具有更大的稳定性。FMIQ也是在不含普朗尼克F-68的情况下配制的，并且基于全氟化学品（FMIQ），其组织停留时间比Fluosol中的全氟三丙胺短;因此，其产生的副作用可能比Fluosol少。BALB/c小鼠中循环全氟化合物液滴的寿命长于FMIQ，而不是Fluosol;这可以在分次放疗中提供优势。这些发现使我们有理由期待，FMIQ可能被证明是一种比Fluosol更好的乳剂，可用于临床癌症治疗的辅助治疗。
The effects of FMIQ, a perfluorochemical emulsion based on perfluoro-N-methyldecahydroisoquinoline, were examined using BALB/c mice and EMT6 mammary carcinomas. The radiobiological effects of FMIQ were similar to those found previously for Fluosol® in the same tumour/host system. Although the perfluorochemical content (20% w/v) and oxygen-carrying capacity of FMIQ are similar to those of Fluosol, the formulation of FMIQ offers some advantages over that of Fluosol. For example, FMIQ has greater stability during storage. FMIQ also is fomulated without pluronic F-68 and is based on a perfluorochemical (FMIQ) having a shorter tissue dwell time than the perfluorotripropylamine in Fluosol; it therefore may produce fewer side-effects than Fluosol. The lifetime of the circulating perfluorochemical droplets in BALB/c mice was longer than FMIQ than for Fluosol; this could offer an advantage in fractionated radiotherapy. These findings give reason to expect that FMIQ may prove to be a better emulsion than Fluosol for clinical use as an adjunct to cancer therapy.