Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is associated with high parasitemia but not severe clinical manifestations of malaria in African children
Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is associated with high parasitemia but not severe clinical manifestations of malaria in African children
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DOI：
10.4269/ajtmh.2007.77.943
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发表时间：
2007-11-01
影响因子：
3.3
通讯作者：
Rowe, J. Alexandra
中科院分区：
文献类型：
--
作者：
Arman, Monica;Raza, Ahmed;Rowe, J. Alexandra
血小板介导的恶性疟原虫感染红细胞的聚集是一种粘附性表型，在以前与严重疟疾有关的野外分离株中常见。在这里，对来自马里儿童的131个分离株进行了聚集性评估。6%(N=51)的无并发症疟疾分离株、24%(N=51)的重度疟疾分离株和45%(N=29)的高原虫血症非严重疟疾分离株出现聚集性表型。多因素分析显示，聚集性与寄生虫血症呈显著正相关(F-1，F-122=24.1，P<；0.001)，而与疾病类别无关(F-2，F-122=1.8，P=0.17)。因此，在马里恶性疟原虫分离株中，平板凝集主要与高寄生虫血症有关，而与疟疾的严重临床表现无关。
Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is an adhesive phenotype commonly found in field isolates that has previously been associated with severe malaria. Here, clumping was assessed in 131 isolates from Malian children. The clumping phenotype was seen in 6% (N = 51) of uncomplicated malaria, 24% (N = 51) of severe malaria, and 45% (N = 29) of high parasitemia non-severe malaria isolates. Multivariate analysis indicated that clumping was strongly positively associated with parasitemia (F-1,F-122 = 24.1, P < 0.001) but not with disease category (F-2,F-122 = 1.8, P = 0.17). Therefore plate let-mediated clumping in Malian P. falciparum isolates is primarily associated with high parasitemia and not with severe clinical manifestations of malaria.