Principal neurons of the lumbar sympathetic ganglia increase in number with body size.
Principal neurons of the lumbar sympathetic ganglia increase in number with body size.
复制标题
腰交感神经节的主要神经元数量随着身体尺寸的增加而增加。
DOI：
10.1002/cne.903570111
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Farel,PB
中科院分区：
文献类型：
--
作者：
StWecker,PG;Baek,JK;Farel,PB
在早期发育过程中，通过调节增殖过程和自然发生的细胞死亡，神经元的数量似乎与身体的大小相匹配。然而，在这些过程停止很长一段时间后，随着幼体成为成年人，体型迅速增加。本研究表明，在牛蛙变态后的生活中，腰交感神经节的主神经元数量增加了四到五倍。神经元数量的增加既不能归因于计数错误，也不能归因于选择偏差，而是与特定后肢靶点的更多神经支配有关，辣根过氧化物酶逆行标记证明了这一点。每隔三天注射一次[~3H]胸腺嘧啶核苷(DNA合成的标志)，持续20-22周，未能提供神经元增殖的证据，尽管在此期间，根据体长的变化，可能增加了大量神经元。这些结果结合以前对后肢运动和感觉神经元增加的研究，与交感神经元的数量随着现有前体细胞的晚期分化而增加的假设是一致的。©1995 Wiley-Liss公司
Neuron number appears to be matched to body size during early development by the modulation of the processes of proliferation and naturally occurring cell death. However, body size increases rapidly as the juvenile becomes an adult, long after these processes cease to operate. The present study shows that principal neurons of lumbar sympathetic ganglia increase in number four‐ to fivefold during postmetamorphic life of the bullfrog,Rana catesbeiana. This increase in neuron number cannot be attributed to either counting error or selection bias and was associated with greater innervation of particular hindlimb targets, as demonstrated by retrograde labeling with horseradish peroxidase. Injection of [3H] thymidine (a marker of DNA synthesis) every third day for 20‐‐22 weeks failed to provide evidence of neuron proliferation, although, on the basis of changes in body length during this period, substantial numbers of neurons likely were added. These results combined with previous studies of hindlimb motor and sensory neuron addition are consistent with the hypothesis that the population of sympathetic neurons is augmented by late differentiation of existing precursor cells. © 1995 Wiley‐Liss, Inc.