Elevated aspartate aminotransferase and monocyte counts predict unfavorable prognosis in patients with malignant pleural mesothelioma
Elevated aspartate aminotransferase and monocyte counts predict unfavorable prognosis in patients with malignant pleural mesothelioma
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天冬氨酸转氨酶和单核细胞计数升高预示恶性胸膜间皮瘤患者的不良预后
DOI：
10.4149/neo_2017_114
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发表时间：
2017-01-01
期刊：
影响因子：
3
通讯作者：
Yu, Y.
中科院分区：
文献类型：
--
作者：
Zhang, A.;Cao, S.;Yu, Y.
有限的生物标志物预测恶性胸膜间皮瘤（MPM）的预后已经确定。本研究旨在评估MPM的潜在实验室预后因素。我们回顾性分析了105例MPM患者的临床资料。采用Kaplan-Meier曲线和考克斯回归分析评估总生存期和影响预后的因素。进行受试者工作特征（ROC）曲线分析以确定最佳截止值。105例患者（62例男性，43例女性）的平均年龄为56.0岁。主要临床表现为呼吸困难、咳嗽和胸痛。最常见的实验室异常是血小板增多和单核细胞计数升高。单因素分析的显著预后因素为体力状态（PS）、血清白蛋白、天冬氨酸转氨酶（AST）、乳酸脱氢酶（LDH）、碱性磷酸酶（ALP）、单核细胞、血小板与淋巴细胞比率（PLR）、淋巴细胞与单核细胞比率（LMR）和治疗策略。多因素分析显示PS、AST、单核细胞和治疗策略有统计学意义（p
Limited biomarkers predicting prognosis of malignant pleural mesothelioma (MPM) have been identified. The present study aims to assess potential laboratory prognostic factors of MPM. We retrospectively reviewed the clinical data of 105 patients with MPM. The overall survival and prognostic factors were assessed by Kaplan-Meier curves and Cox regression analysis. A receiver operating characteristic (ROC) curve analysis was performed to determine the optimal cut-off values. The mean age of the 105 patients (62 men, 43 women) was 56.0 years. The major clinical presentations were dyspnea, cough and chest pain. The most common laboratory abnormalities were thrombocytosis and elevated monocyte count. Significant prognostic factors on univariate analysis were performance status (PS), serum albumin, aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), monocyte, platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR) and treatment strategy. Multivariate analysis showed PS, AST, monocyte, and treatment strategy were statistically significant (p