MULTIPLE TUMOR SUPPRESSOR GENES IN MULTISTEP CARCINOGENESIS
MULTIPLE TUMOR SUPPRESSOR GENES IN MULTISTEP CARCINOGENESIS
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DOI：
10.1620/tjem.168.149
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发表时间：
1992-10-01
影响因子：
2.2
通讯作者：
KOI, M
中科院分区：
文献类型：
--
作者：
FEINBERG, AP;JOHNSON, LA;KOI, M
分子肿瘤学最令人兴奋的领域之一是两条独立证据的融合，表明多种肿瘤抑制基因参与特定类型的癌症。首先，流行病学和体细胞遗传学表明多种恶性肿瘤中均存在多种肿瘤抑制基因。其次，癌症在肿瘤进展过程中通常会丢失多个染色体区域。我们将使用结直肠癌和肾母细胞瘤这两种肿瘤来说明多个抑癌基因引发的问题。
One of the most exciting areas of molecular oncology is the convergence of two independent lines of evidence suggesting involvement of multiple tumor suppressor genes in a given type of cancer. First, epidemiology and somatic cell genetics indicate the presence of multiple tumor suppressor genes in each of several malignancies. Second, cancers often lose multiple chromosomal regions during tumor progression. We will use two tumors, colorectal cancer and Wilms tumor, to illustrate the questions that multiple tumor suppressor genes raise.