Bitter taste perception and severe vomiting in pregnancy.
Bitter taste perception and severe vomiting in pregnancy.
复制标题
怀孕期间的苦味感觉和严重呕吐。
DOI：
10.1016/s0031-9384(00)00223-7
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发表时间：
2000
影响因子：
2.9
通讯作者：
Duffy,VB
中科院分区：
文献类型：
--
作者：
Sipiora,ML;Murtaugh,MA;Gregoire,MB;Duffy,VB
妊娠剧吐或怀孕期间严重呕吐是一种病因难以捉摸的病症，可能会伤害母亲和胎儿。这项研究探讨了苦味感知增加与妊娠剧吐史之间的关联。苦味感知因基因而异，并且会随着与味觉相关的脑神经受损的情况而改变。根据所有怀孕期间的呕吐暴露情况，将 60 名女性分为高呕吐率组 (n = 21) 和低呕吐率组 (n = 39)，并筛选滤纸上传递的饱和 6-正丙基硫氧嘧啶 (PROP) 的苦味味觉遗传变异。味觉超级者认为 PROP 非常苦；味觉障碍者，味觉较弱。每个人都报告了他们的味觉障碍（持续味觉）和味觉相关病理（中耳炎和头部外伤）的病史。呕吐组的味觉超常者的频率没有差异，但呕吐频繁组的非味觉者最少。高呕吐组也最常报告味觉障碍。子样本（13 名呕吐次数多的女性和 18 名呕吐次数少的女性）评估了将氯化钠（1 摩尔）、蔗糖（1 摩尔）、柠檬酸（0.0032 摩尔）和盐酸奎宁（0.001 摩尔）涂在第七和第九脑神经支配区域的味道强度。各组仅在盐酸奎宁的苦味方面存在显着差异。呕吐较多的女性在前舌（第七鼓索鼓索分支）尝到的苦味最少，在后舌（脑神经 IX）和上颚（第七岩浅支）的苦味最高。在呕吐较多的女性中，后舌和上颚的苦味增加似乎与呕吐物中的盐酸暴露无关；这可以解释味觉障碍的发生。这种空间味觉感知模式可能表明口腔感觉改变，如果在怀孕期间出现这种改变，可能会增加呕吐的风险。
Hyperemesis gravidarum or severe vomiting during pregnancy is a condition of elusive etiology that can harm both mother and fetus. This study examined the association between increased bitter-taste perception and history of hyperemesis gravidarum. Bitter-taste perception varies genetically and can be altered with conditions that damage taste-related cranial nerves. Sixty women were divided into high- (n = 21) and low-vomit (n = 39) groups based on vomiting exposure across all pregnancies and were screened for genetic variation in taste with bitterness of saturated 6-n-propylthiouracil (PROP) delivered on filter paper. Supertasters perceive PROP as intensely bitter; nontasters, as only weakly. Each reported their history of dysgeusia (persistent taste) and taste-related pathology (otitis media and head trauma). The vomit groups did not differ in the frequency of supertasters, but the high-vomit group had fewest nontasters. The high-vomit group also reported dysgeusia most frequently. A subsample (13 high-vomit and 18 low-vomit women) rated the taste intensity of sodium chloride (1 mol), sucrose (1 mol), citric acid (0.0032 mol), and quinine hydrochloride (0.001 mol) applied to areas innervated by cranial nerves VII and IX. The groups only varied significantly in bitterness of quinine hydrochloride. High-vomit women tasted least bitterness on the anterior tongue (chorda tympani branch of VII) and highest bitterness on the posterior tongue (cranial nerve IX) and palate (superficial petrosal branch of VII). In high-vomit women, elevated bitterness on the posterior tongue and palate does not appear related to hydrochloric acid exposure in vomitus; it may explain the occurrence of dysgeusia. This pattern of spatial taste perception may indicate altered oral sensations that if present during pregnancy, could increase the risk of hyperemesis.