A new gliotoxin analogue from a marine-derived fungus Aspergillus fumigatus Fres
A new gliotoxin analogue from a marine-derived fungus Aspergillus fumigatus Fres
复制标题
DOI：
10.1080/14786410600906970
复制
发表时间：
2009-01-01
影响因子：
2.2
通讯作者：
Gu, Qian Qun
中科院分区：
文献类型：
--
作者：
Zhao, Wen Ying;Zhu, Tian Jiao;Gu, Qian Qun
从海洋真菌烟曲霉（Aspergillus fumigatus Fres）的培养物中分离得到一个新的胶胶毒素类似物（1），以及四个已知化合物胶毒素（2）、双硫代双（甲硫基）胶胶毒素（3）、双-N-去甲胶毒素（4）和双脱氢双硫代双（甲硫基）胶毒素（5）。化合物1的结构经波谱分析确定。通过SRB方法评价所有五种化合物对tsFT 210细胞系的细胞毒性作用。
A new gliotoxin analogue (1), as well as four known compounds gliotoxin (2), bisdethiobis (methylthio) gliotoxin (3), bis-N-norgliovictin (4) and didehydrobisdethiobis (methylthio) gliotoxin (5), were isolated from a culture of marine-derived fungus Aspergillus fumigatus Fres. The structure of 1 was determined on the basis of spectroscopic methods. All five compounds were evaluated for the cytotoxic effects on tsFT210 cell line by the SRB method.