The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines

The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines
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DOI：
10.1136/gutjnl-2018-316818
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发表时间：
2018-11-01
期刊：
GUT
影响因子：
24.5
通讯作者：
Williams, Horace R. T.
Williams, Horace R. T.
中科院分区：
医学1区
文献类型：
--
作者：
Mullish, Benjamin H.;Quraishi, Mohammed Nabil;Williams, Horace R. T.

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近年来，全球对粪便微生物群移植（FMT）治疗潜力的兴趣不断增加，特别是由于随机研究将其用作干预措施。这些研究的主要焦点是治疗复发性或难治性艰难梭菌感染（CDI），但也有关于非CDI环境的潜在应用的新证据基础。在英国，提供和管理FMT服务的关键临床利益相关者往往在两个主要专业领域：胃肠病学和微生物学/传染病。虽然英国国家健康与护理卓越研究所（NICE）关于使用FMT治疗复发性或难治性CDI的指南（2014年）已被接受，但英国缺乏明确的基于证据的FMT指南。这导致了英国胃肠病学会（BSG）和卫生保健感染学会（HIS）之间的讨论，并建立了BSG/HIS FMT联合工作组。这份指导文件是联合对话的成果。
Interest in the therapeutic potential of faecal microbiota transplant (FMT) has been increasing globally in recent years, particularly as a result of randomised studies in which it has been used as an intervention. The main focus of these studies has been the treatment of recurrent or refractory Clostridium difficile infection (CDI), but there is also an emerging evidence base regarding potential applications in non- CDI settings. The key clinical stakeholders for the provision and governance of FMT services in the UK have tended to be in two major specialty areas: gastroenterology and microbiology/ infectious diseases. While the National Institute for Health and Care Excellence (NICE) guidance (2014) for use of FMT for recurrent or refractory CDI has become accepted in the UK, clear evidence- based UK guidelines for FMT have been lacking. This resulted in discussions between the British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS), and a joint BSG/HIS FMT working group was established. This guideline document is the culmination of that joint dialogue.