Relaxin Treatment in an Ang-II-Based Transgenic Preeclamptic-Rat Model
Relaxin Treatment in an Ang-II-Based Transgenic Preeclamptic-Rat Model
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DOI：
10.1371/journal.pone.0150743
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发表时间：
2016-03-10
期刊：
影响因子：
3.7
通讯作者：
Dechend, Ralf
中科院分区：
文献类型：
--
作者：
Haase, Nadine;Golic, Michaela;Dechend, Ralf
松弛素是一种与怀孕有关的多肽，可以诱导一氧化氮相关和明胶酶相关的效应，允许血管扩张和与怀孕相关的调整，从而允许分娩。松弛素能控制妊娠期间发生的血流动力学和肾血管适应性变化。人们对松弛素和先兆子痫和心力衰竭的治疗原则已经产生了兴趣。子痫前期是一种妊娠障碍，以高血压、蛋白尿和胎盘异常为特征。我们在一个已建立的转基因先兆子痫大鼠模型中研究了松弛素，在该模型中，表型是由妊娠中期血管紧张素(Ang)-II的产生诱导的。我们在妊娠第9天给先兆子痫大鼠注射重组松弛素。服用松弛素后高血压和蛋白尿未见改善。松弛素不能改变胎儿宫内发育迟缓。心率反应和松弛素水平记录了药物效应。在这个基于Ang-II的先兆子痫模型中，我们不能显示出对先兆子痫的有益效果。
Relaxin is a peptide related to pregnancy that induces nitric oxide-related and gelatinase-related effects, allowing vasodilation and pregnancy-related adjustments permitting parturition to occur. Relaxin controls the hemodynamic and renovascular adaptive changes that occur during pregnancy. Interest has evolved regarding relaxin and a therapeutic principle in preeclampsia and heart failure. Preeclampsia is a pregnancy disorder, featuring hypertension, proteinuria and placental anomalies. We investigated relaxin in an established transgenic rat model of preeclampsia, where the phenotype is induced by angiotensin (Ang)-II production in mid pregnancy. We gave recombinant relaxin to preeclamtic rats at day 9 of gestation. Hypertension and proteinuria was not ameliorated after relaxin administration. Intrauterine growth retardation of the fetus was unaltered by relaxin. Heart-rate responses and relaxin levels documented drug effects. In this Ang-II-based model of preeclampsia, we could not show a salubrious effect on preeclampsia.