Selenium-containing block copolymers and their oxidation-responsive aggregates
Selenium-containing block copolymers and their oxidation-responsive aggregates
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DOI：
10.1039/c0py00144a
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发表时间：
2010-01-01
影响因子：
4.6
通讯作者：
Zhang, Xi
中科院分区：
文献类型：
--
作者：
Ma, Ning;Li, Ying;Zhang, Xi
通过甲苯二异氰酸酯（TDI）与含单硒醚的二元醇的聚合，再用聚乙二醇（PEG）单甲醚封端，合成了含一个疏水性聚硒醚嵌段和两个亲水性聚乙二醇（PEG）嵌段的含硒双亲性嵌段共聚物（PEG-PUSe-PEG）。PEG-PUSe-PEG能够在水溶液中自组装以形成嵌段共聚物聚集体。有趣的是，人们发现，聚集体具有良好的氧化响应性，并在温和的氧化环境（如0.1%H2O2 v/v）中进行结构解离，由于硒化物基团在氧化剂存在下的独特敏感性。与硫化物类似物PEG-PUS-PEG相比，PEG-PUSe-PEG对氧化剂更敏感。预期含硒嵌段共聚物聚集体可应用于药物递送系统领域。
A selenium-containing amphiphilic block copolymer (PEG-PUSe-PEG) with a hydrophobic polyselenide block and two hydrophilic poly(ethylene glycol) (PEG) blocks was synthesized via polymerization of toluene diisocyanate (TDI) with monoselenide-containing diols and subsequent termination with PEG monomethylether. PEG-PUSe-PEG is able to self-assemble in aqueous solution to form block copolymer aggregates. Interestingly, it was found that the aggregates have a good oxidation-responsiveness and undergo a structural dissociation in a mild oxidative environment (such as 0.1% H2O2 v/v) due to the unique sensitivity of selenide groups in presence of oxidants. Compared with the sulfide analogue PEG-PUS-PEG, PEG-PUSe-PEG is more sensitive to oxidants. It is anticipated that selenium-containing block copolymer aggregates may find application in the field of drug delivery systems.