Assessment of resistance to anoikis in ovarian cancer.
Assessment of resistance to anoikis in ovarian cancer.
复制标题
评估卵巢癌的失巢凋亡抵抗力。
DOI：
10.1007/978-1-62703-547-7_26
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Shridhar,Viji
中科院分区：
文献类型：
--
作者：
He,Xiaoping;Chien,Jeremy;Shridhar,Viji
失巢凋亡是由于细胞从细胞外基质脱离而发生的程序性细胞死亡的一种形式，是防止异位细胞生长的关键机制。获得对失巢凋亡的抗性是上皮性卵巢癌细胞在形成转移灶之前在腹水中存活的先决条件。本文介绍了一种体外检测卵巢癌细胞抗失巢凋亡的比色法。
Anoikis, a form of programmed cell death that occurs due to cell detachment from the extracellular matrix, is a critical mechanism in preventing ectopic cell growth. Acquisition of resistance to anoikis is a prerequisite for epithelial ovarian cancer cells to survive in ascitic fluids before forming metastatic foci. Here we describe a colorimetric method for monitoring the resistance of anoikis of ovarian cancer cells in vitro.