Multimodal snapshot spectral imaging for oral cancer diagnostics: a pilot study.
Multimodal snapshot spectral imaging for oral cancer diagnostics: a pilot study.
复制标题
DOI：
10.1364/boe.4.000938
复制
发表时间：
2013-06-01
影响因子：
3.4
通讯作者：
Tkaczyk TS
中科院分区：
文献类型：
--
作者：
Bedard N;Schwarz RA;Hu A;Bhattar V;Howe J;Williams MD;Gillenwater AM;Richards-Kortum R;Tkaczyk TS
光学成像和光谱学已经成为检测口腔癌相关恶性变化的有效工具。虽然临床研究已经证明了检测的高灵敏度和特异性，但当前的设备要么询问小区域，要么对于一些良性病变具有降低的性能。我们描述了一种快照成像光谱仪，它结合了大视场的宽视场成像与光谱诊断强度。该便携式设备可以以每秒7.2帧的速度传输RGB图像，并在不到1秒的时间内记录自体荧光和反射光谱数据。我们报告了正常志愿者和口腔癌患者的初步数据。
Optical imaging and spectroscopy have emerged as effective tools for detecting malignant changes associated with oral cancer. While clinical studies have demonstrated high sensitivity and specificity for detection, current devices either interrogate a small region or can have reduced performance for some benign lesions. We describe a snapshot imaging spectrometer that combines the large field-of-view of widefield imaging with the diagnostic strength of spectroscopy. The portable device can stream RGB images at 7.2 frames per second and record both autofluorescence and reflectance spectral datacubes in < 1 second. We report initial data from normal volunteers and oral cancer patients.