SWI/SNF Complex-Deficient Soft Tissue Neoplasms: A Pattern-Based Approach to Diagnosis and Differential Diagnosis.
SWI/SNF Complex-Deficient Soft Tissue Neoplasms: A Pattern-Based Approach to Diagnosis and Differential Diagnosis.
复制标题
DOI：
10.1016/j.path.2018.10.006
复制
发表时间：
2019-03-01
影响因子：
--
通讯作者：
Agaimy, Abbas
中科院分区：
文献类型：
--
作者：
Agaimy, Abbas
开关/蔗糖非发酵（SWI/SNF）染色质重塑复合物的不同组分的丢失已越来越多地被认为是一个中心的分子事件，驱动大多数致命的，但在不同的身体器官的组织遗传多样性肿瘤的启动和/或去分化。这篇综述总结并讨论了以SWI/SNF复合物缺乏为特征的原发性软组织肿瘤的形态学和表型多样性，重点是会聚和发散的细胞结构模式。
Loss of different components of the Switch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex has been increasingly recognized as a central molecular event driving the initiation and/or dedifferentiation of mostly lethal but histogenetically diverse neoplasms in different body organs. This review summarizes and discusses the morphologic and phenotypic diversity of primary soft tissue neoplasms characterized by SWI/SNF complex deficiency with an emphasis on convergent and divergent cytoarchitectural patterns.