Toward a molecular definition of long-term memory storage
Toward a molecular definition of long-term memory storage
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DOI：
10.1073/pnas.93.24.13445
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发表时间：
1996-11-26
影响因子：
11.1
通讯作者：
Kandel, ER
中科院分区：
文献类型：
--
作者：
Bailey, CH;Bartsch, D;Kandel, ER
长期记忆的储存与基因表达的细胞程序、改变的蛋白质合成和新突触连接的生长有关。最近对各种记忆过程的研究，从无脊椎动物简单形式的内隐学习到哺乳动物更复杂形式的外显学习，表明巩固长期记忆所需分子开关的一部分是cAMP诱导的基因级联的激活和cAMP反应元件结合蛋白相关转录因子的募集。这种与学习相关的突触可塑性机制中的保守步骤表明了认知的分子生物学的可能性。
The storage of long-term memory is associated with a cellular program of gene expression, altered protein synthesis, and the growth of new synaptic connections, Recent studies of a variety of memory processes, ranging in complexity from those produced by simple forms of implicit learning in invertebrates to those produced by more complex forms of explicit learning in mammals, suggest that part of the molecular switch required for consolidation of long-term memory is the activation of a cAMP-inducible cascade of genes and the recruitment of cAMP response element binding protein-related transcription factors. This conservation of steps in the mechanisms for learning-related synaptic plasticity suggests the possibility of a molecular biology of cognition.