Associations of EDNRA and EDNRB Polymorphisms with Intracerebral Hemorrhage
Associations of EDNRA and EDNRB Polymorphisms with Intracerebral Hemorrhage
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EDNRA 和 EDNRB 多态性与脑出血的关联
DOI：
10.1016/j.wneu.2019.05.186
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发表时间：
2019-09-01
影响因子：
2
通讯作者：
Zhang，Le
中科院分区：
文献类型：
--
作者：
Zeng，Yi;Chen，RuiJuan;Zhang，Le
目的最强的血管收缩剂内皮素1及其受体内皮素受体A（EDNRA）和内皮素受体B（EDNRB）与高血压有关。高血压是脑出血（ICH）的主要危险因素。最近的研究表明，ICH 患者血浆内皮素-1 水平升高，以及 EDNRA 和 EDNRB 遗传变异与缺血性中风之间的关系。本研究的目的是探讨 EDNRA 和 EDNRB 多态性是否通过与血压水平的相互作用与 ICH 相关。方法在本病例对照研究中对 5 个 EDNRA 和 EDNRB 多态性进行了基因分型。结果我们确定 EDNRA rs5333 T 等位基因可能是 ICH 的保护因素（调整优势比 [OR]= 0.638, 95%） CI：0.417–0.977，P= 0.038），而 EDNRB rs5351 A 等位基因可能是 ICH 的危险因素（调整后 OR = 1.476，95% CI：1.042–2.089，P= 0.028）。此外，我们仅发现ICH患者中EDNRA rs5335的GG基因型的舒张压高于GC+CC基因型（91.69±18.77 vs. 84.71±21.48，P=0.004）。结论这些发现支持EDNRA和EDNRB多态性在ICH中的重要作用，并表明它们不存在相互作用。有血压的 改变 ICH 风险的水平。
ObjectiveThe most potent vasoconstrictor, endothelin-1 and its receptors, endothelin receptor A (EDNRA) and endothelin receptor B (EDNRB) are involved in hypertension. Hypertension is a major risk factor of intracerebral hemorrhage (ICH). Recent studies have demonstrated increased plasma endothelin-1 level in ICH patients and relationships between EDNRA and EDNRB genetic variants and ischemic stroke. The aim of the current study was to investigate whether EDNRA and EDNRB polymorphisms are associated with ICH by interacting with blood pressure levels.MethodsFive EDNRA and EDNRB polymorphisms were genotyped in this case-control study.ResultsWe identified that EDNRA rs5333 T allele might be a protective factor of ICH (adjusted odds ratio [OR] = 0.638, 95% CI: 0.417–0.977,P= 0.038), while EDNRB rs5351 A allele could be a risk factor of ICH (adjusted OR = 1.476, 95% CI: 1.042–2.089,P= 0.028). Moreover, we only found that the GG genotype of EDNRA rs5335 had higher diastolic blood pressure than the GC + CC genotypes in ICH patients (91.69 ± 18.77 vs. 84.71 ± 21.48,P= 0.004).ConclusionsThese findings support the important role of EDNRA and EDNRB polymorphisms in ICH, and suggest that they do not interact with blood pressure levels on altering ICH risk.