PHYSIOLOGICAL INTERPRETATIONS BASED ON LUMPED ELEMENT MODELS FIT TO RESPIRATORY IMPEDANCE DATA - USE OF FORWARD INVERSE MODELING
PHYSIOLOGICAL INTERPRETATIONS BASED ON LUMPED ELEMENT MODELS FIT TO RESPIRATORY IMPEDANCE DATA - USE OF FORWARD INVERSE MODELING
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DOI：
10.1109/10.61033
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发表时间：
1990-11-01
影响因子：
4.6
通讯作者：
COSTA, KD
中科院分区：
文献类型：
--
作者：
LUTCHEN, KR;COSTA, KD
较低（<4 Hz）和较高（>32 Hz）频率下的呼吸阻抗（Z/sub rs/）数据需要比呼吸阻力、惯性和顺应性的标准系列组合更复杂的逆模型。一个正向-反向建模方法被用来提供洞察这些更复杂的逆模型中的参数如何反映真实的生理系统。建立了前向模型，以纳入明确的生理和解剖细节。模拟的正演数据然后与可识别的逆模型和与正演模型中的已知细节相关的参数估计进行拟合。它示出，单独的低频数据的逆拟合将不允许由于气道不均匀性和由于组织粘弹性的频率依赖性的频率依赖性之间的区别。对于更高频率的数据，使用基于不对称分支气道网络的前向模型来模拟0.1-128 Hz的Z/sub rs/，其中增加了不均匀外周气道阻塞的量。因此，逆建模更适合于合理地分离气道和组织特性的估计。<>
Respiratory impedance (Z/sub rs/) data at lower (<4 Hz) and higher (>32 Hz) frequencies require more complicated inverse models than the standard series combination of a respiratory resistance, inertance, and compliance. A forward-inverse modeling approach was used to provide insight on how the parameters in these more complicated inverse models reflect the true physiological system. Forward models are set up to incorporate explicit physiological and anatomical detail. Simulated forward data are then fit with identifiable inverse models and the parameter estimates related to the known detail in the forward model. It is shown that inverse fitting of low-frequency data alone will not allow a distinction between frequency dependence due to airway inhomogeneities and frequency dependence due to tissue viscoelasticity. With higher frequency data, a forward model based on an asymmetric branching airways network was used to simulate Z/sub rs/ from 0.1-128 Hz with increasing amounts of nonuniform peripheral airway obstruction. Hence, inverse modeling is more amenable to sensibly separating estimates of airway and tissue properties.<>