Responses of cancer cells induced by photodynamic therapy.
Responses of cancer cells induced by photodynamic therapy.
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DOI：
10.1260/2040-2295.4.1.87
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发表时间：
2013-03
影响因子：
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通讯作者：
T. Kushibiki;T. Hirasawa;S. Okawa;M. Ishihara
中科院分区：
文献类型：
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作者：
T. Kushibiki;T. Hirasawa;S. Okawa;M. Ishihara
光动力疗法（PDT）包括使用光敏剂，然后使用适当波长的激光局部照射肿瘤组织以激活光敏剂。由于在暴露于光动力效应的癌细胞中，多个细胞信号级联同时被激活，因此了解癌细胞对PDT的反应将有助于开发新的干预措施。本文综述了PDT可能引发的细胞死亡信号通路。此外，我们描述了我们关于诱导癌细胞凋亡特异性mirna表达和PDT对癌细胞诱导抗肿瘤免疫的最新发现。更详细地了解与PDT相关的分子机制将有可能提高PDT治疗患者的长期生存率。
Photodynamic therapy (PDT) involves the administration of a photosensitizer, followed by local irradiation of tumor tissues using a laser of an appropriate wavelength to activate the photosensitizer. Since multiple cellular signaling cascades are concomitantly activated in cancer cells exposed to the photodynamic effect, understanding the responses of cancer cells to PDT will aid in the development of new interventions. This review describes the possible cell-death signaling pathways initiated by PDT. In addition, we describe our latest findings regarding the induction of expression of miRNAs specific to apoptosis in cancer cells and the induction of antitumor immunity following PDT against cancer cells. A more detailed understanding of the molecular mechanisms related to PDT will potentially improve long-term survival of PDT treated patients.