Serum HBV Core-Related Antigen Is a Good Predictor for Spontaneous HBeAg Seroconversion in Chronic Hepatitis B Patients
Serum HBV Core-Related Antigen Is a Good Predictor for Spontaneous HBeAg Seroconversion in Chronic Hepatitis B Patients
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DOI：
10.1002/jmv.24657
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发表时间：
2017-03-01
影响因子：
12.7
通讯作者：
Wei, Lai
中科院分区：
文献类型：
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作者：
Song, Guangjun;Yang, Ruifeng;Wei, Lai
早期预测自发性B病毒e抗原（HBeAg）血清转换对于预防不必要的药物处方、相应的经济负担和不良反应至关重要。对113例免疫活跃期HBeAg阳性的慢性B型肝炎患者进行了1.5年的随访。将患者分为两组：自发HBeAg血清转换组（A组，n = 18）和非自发HBeAg血清转换组。非自发性HBeAg血清转换组35例作为对照组（B组，n = 35）。在第12周，两组之间的B型肝炎核心相关抗原（HBcrAg）水平存在显著差异（B 5.16 +/- 0.53 log（10）kU/ml，P = 0.004），并且在第28周时该显著性放大。仅纳入了两个变量，HBcrAg水平和第28周HBcrAg水平（DHBcrAg）的降低，比值比分别为4.19和0.21。28周时HBcrAg和DHBcrAg的最佳临界值分别为4.90和2.00 log 10 kU/ml。28周HBcrAg阳性预测值为73.9%，阴性预测值为96.7%。28周时DHBcrAg阳性预测值为76.2%，阴性预测值为93.8%。HBcrAg的检测有助于监测慢性B型肝炎病毒感染的自然病程。HBcrAg动态变化可准确预测HBeAg自发血清转换。(C)2016 Wiley Periodicals，Inc.
Early prediction of spontaneous hepatitis B virus e antigen (HBeAg) seroconversion is pivotal in the prevention of unnecessary drug prescription, corresponding financial burden, and adverse reactions. One hundred and thirteen chronic hepatitis B patients with HBeAg-positive in the immune active phase were followed up for about 1.5 years. Patients were classified into two groups: spontaneous HBeAg seroconversion group (group A, n = 18) and nonspontaneous HBeAg seroconversion group. Among the non-spontaneous HBeAg seroconversion group, 35 patients were selected as controls (group B, n = 35). At week 12, there was a significant difference in hepatitis B corerelated antigen (HBcrAg) levels between the two group B 5.16 +/- 0.53 log(10) kU/ml, P = 0.004), and this significance magnified at week 28. Only two variables, HBcrAg level and the reduction in the HBcrAg levels (DHBcrAg) at week 28 were enrolled, with the odds ratio of 4.19 and 0.21, respectively. The optimal cutoffs of HBcrAg levels and the DHBcrAg at week 28 were 4.90 and 2.00 log10 kU/ml, respectively. The positive predictive value and negative predictive value of HBcrAg levels at week 28 were 73.9% and 96.7%, respectively. The positive predictive value and negative predictive value of the DHBcrAg at week 28 were 76.2% and 93.8%, respectively. The measurement of HBcrAg is useful for monitoring the natural course of chronic hepatitis B virus infection. The dynamics of HBcrAg levels could accurately predict the spontaneous HBeAg seroconversion. (C) 2016 Wiley Periodicals, Inc.