Disorders of smell, taste, and food intake in a patient with a dorsomedial thalamic infarct
Disorders of smell, taste, and food intake in a patient with a dorsomedial thalamic infarct
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DOI：
10.1161/01.str.27.12.2328
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发表时间：
1996-12-01
期刊：
影响因子：
8.3
通讯作者：
Romon, M
中科院分区：
文献类型：
--
作者：
Rousseaux, M;Muller, P;Romon, M
背景我们报告说，一个持久的赤字，在享乐性质的嗅觉和味觉知觉可以观察到在双边背内侧和intralaminar丘脑insulines.Case描述一个68岁的病人突然提出了警觉性障碍与嗅觉和味觉知觉减少。观察到食物食欲严重下降，体重减轻10公斤，但随着时间的推移，这些情况部分逆转。两年后，主要的持续性障碍是感知质量的变化：气味和味道要么以中性的方式感知，它们令人愉快的特征消失了，要么是令人不愉快的。但身份被保留了下来。MRI显示病变主要累及丘脑背内侧核及其邻近的板内核团。结论本例提示丘脑背内侧核可能在食物的享乐知觉中起作用，从而影响食物摄入的短期调节，并可能在体重的长期控制中起作用。
Background We report that a lasting deficit in the hedonic character of olfactory and gustatory perception can be observed in bilateral dorsomedial and intralaminar thalamic lesions.Case Description A 68-year-old patient abruptly presented with vigilance disorders associated with a reduction of olfactory and gustatory perceptions. A severe drop in appetite for foods and a weight loss of 10 kg were observed, which were partially reversed with time. Two years later, the main persisting disorder was a change in the quality of perceptions: odors and taste were perceived either in a neutral way, their pleasant character having disappeared, or as unpleasant. However, identification was preserved. MRI showed that lesions principally involved the dorsomedial thalamic nuclei and the adjacent part of the intralaminar nuclei.Conclusions This case suggests that the dorsomedial thalamus may play a role in the hedonic perception of food, thus affecting short-term regulation of food intake, and may possibly have a role in the long-term control of body weight.