Dimethyl fumarate induces changes in B- and T-lymphocyte function independent of the effects on absolute lymphocyte count
Dimethyl fumarate induces changes in B- and T-lymphocyte function independent of the effects on absolute lymphocyte count
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DOI：
10.1177/1352458517707069
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发表时间：
2018-05-01
影响因子：
5.8
通讯作者：
Piccio, Laura
中科院分区：
文献类型：
--
作者：
Longbrake, Erin E.;Cantoni, Claudia;Piccio, Laura
背景：富马酸二甲酯（DMF）用于治疗复发性多发性硬化症，并导致治疗个体亚群中淋巴细胞减少症。关于该药物如何影响B和T淋巴细胞，仍有很多有待了解。目的：描述DMF诱导的B和T细胞表型和功能变化，并研究低绝对淋巴细胞计数（ALC）是否与独特的功能变化相关。方法：从DMF治疗患者、未治疗患者和健康对照中收集外周血单核细胞（PBMCs）。DMF治疗的一个亚组患者淋巴细胞减少（ALC
Background: Dimethyl fumarate (DMF) is used to treat relapsing multiple sclerosis and causes lymphopenia in a subpopulation of treated individuals. Much remains to be learned about how the drug affects B- and T-lymphocytes.Objectives: To characterize changes in B- and T-cell phenotype and function induced by DMF and to investigate whether low absolute lymphocyte count (ALC) is associated with unique functional changes.Methods: Peripheral blood mononuclear cells (PBMCs) were collected from DMF-treated patients, untreated patients, and healthy controls. A subset of DMF-treated patients was lymphopenic (ALC