THE BLEEDING-TIME IN NORMAL SUBJECTS IS MAINLY DETERMINED BY PLATELET VONWILLEBRAND-FACTOR AND IS INDEPENDENT FROM BLOOD-GROUP
THE BLEEDING-TIME IN NORMAL SUBJECTS IS MAINLY DETERMINED BY PLATELET VONWILLEBRAND-FACTOR AND IS INDEPENDENT FROM BLOOD-GROUP
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DOI：
10.1016/0049-3848(92)90210-2
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发表时间：
1992-03-01
影响因子：
7.5
通讯作者：
TOSETTO, A
中科院分区：
文献类型：
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作者：
RODEGHIERO, F;CASTAMAN, G;TOSETTO, A
出血时间(BT)是评价一次止血效果的最重要的体内试验。正常人血浆von Willebrand因子(VWF)与BT无相关性，而正常人血小板vWF与血型或BT的关系尚无相关资料。为了阐明血型、vWF和BT之间的相互关系，我们对177名正常人进行了研究。分析了116例受试者血型对BT的影响，以及111例受试者不同血型间血小板和血浆vWF的分布。此外，在50名受试者中，应用包括年龄、血小板计数、血浆和血小板vWF：Ag和RiCof、红细胞压积、性别和O型或非O型血型在内的多因素回归模型来评估这些变量对BT的联合影响。O组与非O组BT相似(P=0.310)，尽管O组血浆vWF显著低于O组(P<0.001)，但血小板vWF含量分布相似(P=0.873 vWF：Ag和P=0.322 RiCof)。此外，血小板vWF与血浆vWF无相关性(r=0.06，P=0.526)。在多元回归分析中，只有血小板vWF、年龄和血小板计数与BT呈显著负相关(P=0.004)，解释了本试验总变异的25%。因此，血小板vWF是BT的主要决定因素。
Bleeding time (BT) is the most important test "in vivo" evaluating the primary hemostasis. No relationship between plasma von Willebrand factor (vWF) and BT has been found in normal subjects, whereas no data are available on the relationship between platelet vWF and blood group or BT in normal subjects. To clarify the reciprocal relationship between blood group, vWF and BT, we studied 177 normal subjects. The influence of blood group on BT was analyzed in 116 subjects and the distribution of platelet and plasma vWF between different blood groups in 111 subjects. Furthermore, in a subgroup of 50 subjects, a multivariate regression model, including age, platelet count, plasma and platelet vWF:Ag and Ristocetin Cofactor (RiCof), hematocrit, sex and O or non-O blood group was used to assess the joint influence of these variables on BT. BT was similar in O and non-O group (P = 0.310) and, although plasma vWF was significantly lower in O group (P < 0.001), platelet vWF content was similarly distributed (P = 0.873 VWF:Ag and P = 0.322 RiCof). Furthermore, platelet vWF was not correlated with plasma vWF (r = 0.06, P = 0.526). In the multivariate regression analysis, only platelet vWF, age and platelet count showed a significant, inverse correlation with BT (P = 0.004), explaining 25% of the total variation of this test. Platelet vWF resulted therefore the main determinant of BT.