Collective alignment of polar filaments by molecular motors.
Collective alignment of polar filaments by molecular motors.
复制标题
通过分子马达集体排列极性丝。
DOI：
10.1140/epje/i2008-10434-0
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Aranson,IS
中科院分区：
文献类型：
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作者：
Ziebert,F;Vershinin,M;Gross,SP;Aranson,IS
我们研究了极性生物细丝的排列，如微管和肌动蛋白，受到同时连接到多个细丝的多个分子马达的作用。聚焦于一个只有两个细丝与多个马达相互作用的范例模型，我们能够详细地研究排列动力学。虽然在单个电机的情况下几乎不会发生对齐，但由于电机的集体作用，灯丝会迅速对齐。我们的分析表明，对准时间由约束电机的数量和电机步进起伏的大小决定。我们预测排列的时间尺度在秒的数量级，比报道的被动交联束诱导的排列快得多。在体外实验中，多电机覆盖的小球排列微管的结果与定性一致。我们还讨论了另一种快速对准细丝的方式，即电机和无源交联器之间的合作。
We study the alignment of polar biofilaments, such as microtubules and actin, subject to the action of multiple molecular motors attached simultaneously to more than one filament. Focusing on a paradigm model of only two filaments interacting with multiple motors, we were able to investigate in detail the alignment dynamics. While almost no alignment occurs in the case of a single motor, the filaments become rapidly aligned due to the collective action of the motors. Our analysis shows that the alignment time is governed by the number of bound motors and the magnitude of the motors’ stepping fluctuations. We predict that the time scale of alignment is in the order of seconds, much faster than that reported for passive crosslink-induced bundling.In vitroexperiments on the alignment of microtubules by multiple-motor covered beads are in qualitative agreement. We also discuss another mode of fast alignment of filaments, namely the cooperation between motors and passive crosslinks.