Printability of External and Internal Structures Based on Digital Light Processing 3D Printing Technique
Printability of External and Internal Structures Based on Digital Light Processing 3D Printing Technique
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DOI：
10.3390/pharmaceutics12030207
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发表时间：
2020-03-01
期刊：
影响因子：
5.4
通讯作者：
Yang, Gengshen
中科院分区：
文献类型：
--
作者：
Yang, Yan;Zhou, Yanjun;Yang, Gengshen
桌面数字光处理（DLP）打印机的高打印效率和易获得性，使DLP 3D打印成为一种有前途的技术，具有越来越广阔的应用前景，特别是在个性化医疗方面。本研究的目的是使用DLP技术制造和评估具有外部和内部结构的医学样品。不同的添加剂和印刷参数的印刷适性和功能的这种技术的影响进行了彻底的评估。据观察，印刷适性和机械性能的外部结构的聚（乙二醇）二丙烯酸酯（PEGDA）的浓度，增塑剂，层的高度，和曝光时间的影响。3D外部和内部结构的最佳打印解决方案分别为100%PEGDA和75%PEGDA与0.25 mg/mL柠檬黄。最佳层厚分别为0.02 mm和0.05 mm。优化后的微球具有良好的载药性能、缓释性能和生物力学性能。相反，内部结构的可印刷性受光吸收剂、PEGDA浓度、层高度和曝光时间的影响。具有内部结构的优化样品具有良好的形态、完整性和灌注行为。本研究表明，DLP打印技术能够制造用于药物递送的植入物和用于体内评价的生理通道。
The high printing efficiency and easy availability of desktop digital light processing (DLP) printers have made DLP 3D printing a promising technique with increasingly broad application prospects, particularly in personalized medicine. The objective of this study was to fabricate and evaluate medical samples with external and internal structures using the DLP technique. The influence of different additives and printing parameters on the printability and functionality of this technique was thoroughly evaluated. It was observed that the printability and mechanical properties of external structures were affected by the poly(ethylene glycol) diacrylate (PEGDA) concentration, plasticizers, layer height, and exposure time. The optimal printing solutions for 3D external and internal structures were 100% PEGDA and 75% PEGDA with 0.25 mg/mL tartrazine, respectively. And the optimal layer height for 3D external and internal structures were 0.02 mm and 0.05 mm, respectively. The optimal sample with external structures had an adequate drug-loading ability, acceptable sustained-release characteristics, and satisfactory biomechanical properties. In contrast, the printability of internal structures was affected by the photoabsorber, PEGDA concentration, layer height, and exposure time. The optimal samples with internal structures had good morphology, integrity and perfusion behavior. The present study showed that the DLP printing technique was capable of fabricating implants for drug delivery and physiological channels for in vivo evaluation.