Dissociable neural responses in human reward systems
Dissociable neural responses in human reward systems
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DOI：
10.1523/jneurosci.20-16-06159.2000
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发表时间：
2000-08-15
影响因子：
5.3
通讯作者：
Dolan, RJ
中科院分区：
文献类型：
--
作者：
Elliott, R;Friston, KJ;Dolan, RJ
奖励是影响行为的最重要因素之一。在实验动物中进行的单单位记录和损伤研究表明，许多区域对强化刺激有反应，特别是扩展边缘系统和腹侧纹状体的区域。本实验采用功能性神经影像学方法，研究了不同心理情境下人类奖赏系统的神经反应。9名健康志愿者在执行赌博任务时使用功能性磁共振成像进行扫描，并进行经济奖励和惩罚。我们证明了中脑和腹侧纹状体区域对经济奖励的神经敏感性和海马对经济惩罚的敏感性。此外，我们发现，在苍白球，丘脑和扣带回的神经反应是特定的高奖励水平的背景下，不断增加的奖励。在增加奖励的背景下，奖励水平和惩罚水平的背景下，增加惩罚的反应，在尾状核，腹侧前额叶皮层。这些结果表明，可分离的神经反应的奖励和惩罚，是依赖于他们所经历的心理背景。
Reward is one of the most important influences shaping behavior. Single-unit recording and lesion studies in experimental animals have implicated a number of regions in response to reinforcing stimuli, in particular regions of the extended limbic system and the ventral striatum. In this experiment, functional neuroimaging was used to assess neural response within human reward systems under different psychological contexts. Nine healthy volunteers were scanned using functional magnetic resonance imaging during the performance of a gambling task with financial rewards and penalties. We demonstrated neural sensitivity of midbrain and ventral striatal regions to financial rewards and hippocampal sensitivity to financial penalties. Furthermore, we show that neural responses in globus pallidus, thalamus, and subgenual cingulate were specific to high reward levels occurring in the context of increasing reward. Responses to both reward level in the context of increasing reward and penalty level in the context of increasing penalty were seen in caudate, insula, and ventral prefrontal cortex. These results demonstrate dissociable neural responses to rewards and penalties that are dependent on the psychological context in which they are experienced.