Optoacoustic imaging of the prostate: development toward image-guided biopsy
Optoacoustic imaging of the prostate: development toward image-guided biopsy
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DOI：
10.1117/1.3333548
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发表时间：
2010-03-01
影响因子：
3.5
通讯作者：
Oraevsky, Alexander A.
中科院分区：
文献类型：
--
作者：
Yaseen, Mohammad A.;Ermilov, Sergey A.;Oraevsky, Alexander A.
光声 (OA) 断层扫描已被证明可用于识别乳腺组织中富含血液的恶性肿瘤。我们描述了前列腺激光 OA 成像系统 (LOIS-P) 的开发和表征。该系统由工作波长为 757 nm 的光纤耦合 Q 开关激光器、商用 128 通道超声波探头、数字信号处理器以及使用滤波径向背投影算法进行图像重建的软件组成。该系统用于重建犬前列腺体内富血病变的 OA 图像。将体内获得的 OA 图像与使用超声波获取的图像进行比较，超声波是目前指导前列腺活检的金标准。虽然两种成像技术都可以识别尿道等关键结构特征，但代表高度血管化肿瘤的血性病变只能在 OA 图像中清晰识别。还通过收集模拟组织内血管的模型的 OA 图像来评估前向和后向照明模式的优点和局限性。声学阵列径向上的系统分辨率估计为 0.2 mm。最小可检测压力信号为 1.83 Pa。我们的结果鼓励进一步开发用于前列腺成像和图像引导活检的双模 OA/超声系统。 (C) 2010 年光电仪器工程师协会。 [DOI：10.1117/1.3333548]
Optoacoustic (OA) tomography has demonstrated utility in identifying blood-rich malignancies in breast tissue. We describe the development and characterization of a laser OA imaging system for the prostate (LOIS-P). The system consists of a fiber-coupled Q-switched laser operating at 757 nm, a commercial 128-channel ultrasonic probe, a digital signal processor, and software that uses the filtered radial back-projection algorithm for image reconstruction. The system is used to reconstruct OA images of a blood-rich lesion induced in vivo in a canine prostate. OA images obtained in vivo are compared to images acquired using ultrasound, the current gold standard for guiding biopsy of the prostate. Although key structural features such as the urethra could be identified with both imaging techniques, a bloody lesion representing a highly vascularized tumor could only be clearly identified in OA images. The advantages and limitations of both forward and backward illumination modes are also evaluated by collecting OA images of phantoms simulating blood vessels within tissue. System resolution is estimated to be 0.2 mm in the radial direction of the acoustic array. The minimum detectable pressure signal is 1.83 Pa. Our results encourage further development toward a dual-modality OA/ultrasonic system for prostate imaging and image-guided biopsy. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3333548]