Interfacing Perforated Eardrums with Graphene‐Based Membranes for Broadband Hearing Recovery
Interfacing Perforated Eardrums with Graphene‐Based Membranes for Broadband Hearing Recovery
复制标题
将穿孔鼓膜与石墨烯薄膜连接以实现宽带听力恢复
DOI：
10.1002/adhm.202201471
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发表时间：
2022-07
期刊：
影响因子：
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通讯作者：
Shankai Yin
中科院分区：
文献类型：
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作者：
Chunyan Li;Zhiyuan Xiong;Lei Zhou;Weiluo Huang;Yushi He;Linpeng Li;Haibo Shi;Jiayu Lu;Jian Wang;Dan Li;Shankai Yin
鼓膜穿孔和相关的听力损失是一个全球性的健康问题。临床上用自体组织移植穿孔鼓膜可恢复低频听力，但高频听力恢复较差。在这项研究中，将薄的多层石墨烯膜（MGM）纳入鼓膜的宽带听力恢复大鼠的潜力进行了检查。MGM具有良好的生物相容性和生物稳定性，可促进鼓膜细胞以可调节的方式生长，几乎没有组织排斥反应和炎症反应的迹象。在植入三周后，发现MGM被两侧的新生长组织的薄层包裹，而没有在自然愈合中经常看到的显著折叠过度生长。穿孔密封良好，启用宽带听力恢复（1-32 kHz）并维持至少2个月。力学模拟表明，MGM的高弹性模量和薄的重建鼓膜厚度在高频听力的恢复中起着关键作用。这项工作证明了使用MGM作为穿孔鼓膜的功能移植物以恢复宽带频率区域中的听力的前景，并提出了石墨烯相关2D材料的新的声学相关医疗应用。
Eardrum perforation and associated hearing loss is a global health problem. Grafting perforated eardrum with autologous tissues in clinic can restore low-frequency hearing but often leaves poor recovery of high-frequency hearing. In this study, the potential of incorporating a thin multilayered graphene membrane (MGM) into the eardrum for broadband hearing recovery in rats is examined. The MGM shows good biocompatibility and biostability to promote the growth of eardrum cells in a regulated manner with little sign of tissue rejection and inflammatory response. After three weeks of implantation, the MGM is found to be encapsulated by a thin layer of newly grown tissue on both sides without a significant folded overgrowth that is often seen in natural healing. The perforation is well sealed, and broadband hearing recovery (1-32 kHz) is enabled and maintained for at least 2 months. Mechanical simulations show that the high elastic modulus of MGM and thin thickness of the reconstructed eardrum play a critical role in the recovery of high-frequency hearing. This work demonstrates the promise of the use of MGM as a functional graft for perforated eardrum to recover hearing in the broadband frequency region and suggests a new acoustics-related medical application for graphene-related 2D materials.