Cocrystal dissociation and molecular demixing in the solid state.
Cocrystal dissociation and molecular demixing in the solid state.
复制标题
固态下的共晶解离和分子分层。
作者：
M. Eddleston;G. Lloyd;W. Jones
人们发现一种含有咖啡因和茶碱的新共晶体在加热时会解离，咖啡因和茶碱分子会自发地分层并作为单独的相重结晶，这可能是由熵增加驱动的固-固转变。通过透射电子显微镜测定所得晶体的形态和组成。
A new cocrystal containing caffeine and theophylline was found to dissociate on heating, with caffeine and theophylline molecules spontaneously demixing and recrystallizing as separate phases, in a solid-solid transition likely driven by an increase in entropy. The morphology and composition of the resulting crystals was determined by transmission electron microscopy.