Epstein-Barr virus frequency in primary central nervous system lymphomas in Turkey
Epstein-Barr virus frequency in primary central nervous system lymphomas in Turkey
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DOI：
10.1111/j.1600-0463.2012.02961.x
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发表时间：
2013-03-01
期刊：
影响因子：
2.8
通讯作者：
Uner, Aysegul
中科院分区：
文献类型：
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作者：
Saglam, Arzu;Akyurek, Nalan;Uner, Aysegul
张建军，张建军，张建军，等。土耳其原发性中枢神经系统淋巴瘤的研究进展。学院2013年;121: 232 - 8。原发性中枢神经系统（CNS）淋巴瘤是一种罕见的肿瘤，在免疫功能正常的患者中通常与eb病毒无关。本研究的目的是调查EBV在土耳其人群原发性中枢神经系统淋巴瘤中的发病率。根据WHO 2008标准诊断的32例原发性中枢神经系统淋巴瘤纳入本研究。利用EBV编码的小RNA寡核苷酸进行原位杂交，研究了EBV小核糖核酸的存在。免疫组织化学检测CD10、Bcl-6、MUM-1/IRF-4、Bcl-2、Ki-67的表达。患者队列包括20名男性患者和12名女性患者，中位年龄为53.5岁（范围1375）。根据Hans标准，7例（22%）为生发中心型（GC）， 25例（78%）为非GC表型。Bcl-2强表达26例（81%），Ki-67指数中位数为78%。4例原发性中枢神经系统淋巴瘤（12.5%）中有EBV表达。原发性中枢神经系统淋巴瘤多为非gc型，Bcl-2高表达，增殖率高。土耳其原发性中枢神经系统淋巴瘤中EBV的发病率似乎高于西方国家。
Saglam A, Akyurek N, Soylemezoglu F, Uner A. Epstein-Barr frequency in primary central nervous system lymphomas in Turkey. APMIS 2013; 121: 232-8.Primary central nervous system (CNS) lymphomas are rare neoplasms which are usually not associated with Epstein-Barr virus (EBV) in immunocompetent patients. The aim of this study was to investigate the incidence of EBV in primary CNS lymphomas in the Turkish population. Thirty-two primary CNS lymphomas diagnosed according to the WHO 2008 criteria were included in this study. The presence of EBV small ribonucleic acids was investigated by in situ hybridization using EBV encoded small RNA oligonucleotides. The expression of CD10, Bcl-6, MUM-1/IRF-4, Bcl-2, and Ki-67 were evaluated using immunohistochemistry. The patient cohort included 20 male patients and 12 female patients with a median age of 53.5years (range 1375). Seven (22%) of cases were classified as germinal center (GC) and 25 (78%) cases as non-GC phenotype according to the Hans criteria. Twenty-six (81%) of the cases showed strong Bcl-2 expression and the median Ki-67 index was 78%. EBV expression was observed in four primary CNS lymphoma cases (12.5%). Most primary CNS lymphomas show non-GC phenotype with high Bcl-2 expression and high proliferative rate. The incidence of EBV in primary CNS lymphomas from Turkey appears to be higher than that observed in the Western countries.