Senescence and the Aging Immune System as Major Drivers of Chronic Kidney Disease.
Senescence and the Aging Immune System as Major Drivers of Chronic Kidney Disease.
复制标题
衰老和免疫系统老化是慢性肾脏病的主要驱动因素。
DOI：
10.3389/fcell.2020.564461
复制
发表时间：
2020
影响因子：
5.5
通讯作者：
Henson SM
中科院分区：
文献类型：
--
作者：
Schroth J;Thiemermann C;Henson SM
Chronic kidney disease (CKD) presents an ever-growing disease burden for the world’s aging population. It is characterized by numerous changes to the kidney, including a decrease in renal mass, renal fibrosis, and a diminished glomerular filtration rate. The premature aging phenotype observed in CKD is associated with cellular senescence, particularly of renal tubular epithelial cells (TECs), which contributes to chronic inflammation through the production of a proinflammatory senescence associated secretory phenotype (SASP). When coupled with changes in immune system composition and progressive immune dysfunction, the accumulation of senescent kidney cells acts as a driver for the progression of CKD. The targeting of senescent cells may well present an attractive therapeutic avenue for the treatment of CKD. We propose that the targeting of senescent cells either by direct inhibition of pro-survival pathways (senolytics) or through the inhibition of their proinflammatory secretory profile (senomorphics) together with immunomodulation to enhance immune system surveillance of senescent cells could be of benefit to patients with CKD.
