Prognostic value of epithelial-mesenchymal transition circulating tumor cells in female breast cancer: A meta-analysis.
Prognostic value of epithelial-mesenchymal transition circulating tumor cells in female breast cancer: A meta-analysis.
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上皮-间质转化循环肿瘤细胞在女性乳腺癌中的预后价值：荟萃分析
DOI：
10.3389/fonc.2022.1024783
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发表时间：
2022
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
上皮-间质转化（EMT）赋予循环肿瘤细胞（CTC）转移特性，并被认为与乳腺癌患者不良的生存结果相关。然而，关于经历EMT的CTC（EMT-CTC）与乳腺癌预后之间的关系，不同的研究报告了有争议的结果。因此，本荟萃分析旨在探讨 EMT-CTC 对乳腺癌患者的预后作用。总共纳入了来自 Web of Science、Embase 和 PubMed 筛选的 9 项研究的 842 名患者。通过 Kaplan-Meier 生存曲线提取或估计无进展生存期 (PFS) 和总生存期 (OS) 的风险比 (HR) 和 95% 置信区间 (CI)，以进行荟萃分析。进行敏感性分析来表征试验之间的异质性。同时进行亚组分析，呈现癌症分期、鉴定方法、采样量和区域对EMT-CTCs预后价值的影响。 PFS 的汇总 HR 分别为 1.97（单变量：95% CI，1.19-3.24；p = 0.008）和 2.23（多变量：95% CI，1.29-3.86；p = 0.004）。 OS 的汇总 HR 分别为 2.03（单变量：95% CI，1.07-3.84；p = 0.029）和 1.70（多变量：95% CI，1.14-2.52；p = 0.009）。亚组分析显示，EMT-CTC 与原发性乳腺癌组（汇总 HR = 2.58，95% CI，1.66-4.00，p < 0.001）、聚合酶链反应（PCR）组（汇总 HR = 2.69，95% CI，1.66-4.35，p < 0.001）、乳腺癌组的 PFS 相关。 >7.5 ml 组（汇总 HR = 1.93，95% CI，1.36–2.73，p < 0.001）和亚洲组（汇总 HR = 1.92，95% CI，1.13–3.29，p = 0.017）以及原发性乳腺癌组的 OS（汇总 HR = 3.59，95% CI， 1.62–7.95；p = 0.002)。荟萃分析显示，EMT-CTC 与乳腺癌患者较差的生存结果相关。更准确的方法和具有统一标准的设计临床试验对于确定 EMT-CTC 在乳腺癌女性疾病进展中的真正作用至关重要。
Epithelial–mesenchymal transition (EMT) conferred metastatic properties on circulating tumor cells (CTCs) and was considered to be correlated with bad survival outcomes in patients with breast cancer. However, different studies have reported controversial results regarding the relationship between CTCs that have undergone EMT (EMT-CTCs) and prognosis of breast cancer. Therefore, this meta-analysis aimed to investigate the prognostic role of EMT-CTCs in patients with breast cancer. In total, 842 patients from nine studies that were screened from Web of Science, Embase, and PubMed were included. The hazard ratio (HR) and 95% confidence interval (CI) for progression-free survival (PFS) and overall survival (OS) were extracted or estimated by the Kaplan–Meier survival curve for the meta-analysis. Sensitivity analysis was performed to characterize heterogeneity among the trials. Meanwhile, subgroup analysis was performed to present the effects of cancer stage, identification method, sampling volume, and region on the prognostic value of EMT-CTCs. The pooled HRs for PFS were 1.97 (univariate: 95% CI, 1.19–3.24; p = 0.008) and 2.23 (multivariate: 95% CI, 1.29–3.86; p = 0.004). The pooled HRs for OS were 2.03 (univariate: 95% CI, 1.07–3.84; p = 0.029) and 1.70 (multivariate: 95% CI, 1.14–2.52; p = 0.009). Subgroup analysis showed that EMT-CTCs were associated with PFS in the primary breast cancer group (pooled HR = 2.58, 95% CI, 1.66–4.00, p < 0.001), the polymerase chain reaction (PCR) group (pooled HR = 2.69, 95% CI, 1.66–4.35, p < 0.001), the sampling volume of the >7.5-ml group (pooled HR = 1.93, 95% CI, 1.36–2.73, p < 0.001), and the Asia group (pooled HR = 1.92, 95% CI, 1.13–3.29, p = 0.017) and with OS in the primary breast cancer group (pooled HR = 3.59, 95% CI, 1.62–7.95; p = 0.002). The meta-analysis showed that EMT-CTCs were associated with poorer survival outcomes in patients with breast cancer. More accurate methods and designed clinical trials with unified standards are essential to establish the real role of EMT-CTCs in disease progression in women with breast cancer.
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影响因子：
158.5
作者：
Cristofanilli, M;Budd, GT;Hayes, DF
通讯作者：
Hayes, DF
在转移性乳腺癌的患者中，上皮到间质转变中循环肿瘤细胞的鉴定与预后不良有关。
DOI：
10.1186/s13058-016-0687-3
发表时间：
2016-03-09
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Bulfoni M;Gerratana L;Del Ben F;Marzinotto S;Sorrentino M;Turetta M;Scoles G;Toffoletto B;Isola M;Beltrami CA;Di Loreto C;Beltrami AP;Puglisi F;Cesselli D
通讯作者：
Cesselli D
影响因子：
3.8
作者：
Barrière G;Riouallon A;Renaudie J;Tartary M;Rigaud M
通讯作者：
Rigaud M
DOI：
10.1186/bcr3099
发表时间：
2012-01-20
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Kasimir-Bauer S;Hoffmann O;Wallwiener D;Kimmig R;Fehm T
通讯作者：
Fehm T
影响因子：
3.4
作者：
Ito, Mayuko;Horimoto, Yoshiya;Saito, Mitsue
通讯作者：
Saito, Mitsue