Current developments in salivary diagnostics.
Current developments in salivary diagnostics.
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DOI：
10.2217/bmm.09.68
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发表时间：
2010-02
影响因子：
2.2
通讯作者：
McDevitt JT
中科院分区：
文献类型：
--
作者：
Miller CS;Foley JD;Bailey AL;Campell CL;Humphries RL;Christodoulides N;Floriano PN;Simmons G;Bhagwandin B;Jacobson JW;Redding SW;Ebersole JL;McDevitt JT
唾液诊断是一个新兴领域，在过去十年中取得了几项重要进展，包括人类唾液蛋白质组的出版和联邦基金的注入，以将纳米技术和微流体工程概念整合到开发紧凑的即时护理设备中，用于快速分析这种分泌物。在这篇文章中，我们讨论了一些这些发展及其相关性的预后，诊断和牙周炎的管理，作为一个口腔目标，心血管疾病，作为这些生物诊断的潜力的一个系统的例子。我们的研究结果表明，几种生物标志物与这些疾病的不同生物学阶段相关，并显示出作为识别和管理牙周病和急性心肌梗死的实用生物标志物的前景。这些研究中的大多数已经通过生物标志物发现取得了进展，所识别的分子需要更稳健的临床研究才能进行疾病诊断的实质性验证。据预测，随着该领域的不断进步，在多重面板中使用生物标志物的组合可能会在不久的将来产生用于这些诊断的准确筛选工具。
Salivary diagnostics is an emerging field that has progressed through several important developments in the past decade, including the publication of the human salivary proteome and the infusion of federal funds to integrate nanotechnologies and microfluidic engineering concepts into developing compact point-of-care devices for rapid analysis of this secretion. In this article, we discuss some of these developments and their relevance to the prognosis, diagnosis and management of periodontitis, as an oral target, and cardiovascular disease, as a systemic example for the potential of these biodiagnostics. Our findings suggest that several biomarkers are associated with distinct biological stages of these diseases and demonstrate promise as practical biomarkers in identifying and managing periodontal disease, and acute myocardial infarction. The majority of these studies have progressed through biomarker discovery, with the identified molecules requiring more robust clinical studies to enable substantive validation for disease diagnosis. It is predicted that with continued advances in this field the use of a combination of biomarkers in multiplex panels is likely to yield accurate screening tools for these diagnoses in the near future.