KYNURENINE AS AN INTERMEDIATE IN THE FORMATION OF NICOTINIC ACID FROM TRYPTOPHANE BY NEUROSPORA
KYNURENINE AS AN INTERMEDIATE IN THE FORMATION OF NICOTINIC ACID FROM TRYPTOPHANE BY NEUROSPORA
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DOI：
10.1073/pnas.33.6.155
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发表时间：
1947-01-01
影响因子：
11.1
通讯作者：
NYC, JF
中科院分区：
文献类型：
--
作者：
BEADLE, GW;MITCHELL, HK;NYC, JF
基于脉孢菌突变株对烟酰胺、烟酸和犬尿氨酸的生长反应，推测烟酸通常由烟酰胺形成，犬尿氨酸作为中间体。如果这是正确的，犬尿氨酸具有迄今未被怀疑的生物学意义。犬尿氨酸在哺乳动物体内是否作为烟碱和烟酸之间的中间体还有待进一步研究。
On the basis of the growth responses of mutant strains of Neurospora to tryptophane, nicotinic acid and kynurenine, nicotinic acid is assumed to be formed normally from tryptophane, with kynurenine as an intermediate. If this is correct, kynurenine has a biologic significance heretofore unsuspected. Whether kynurenine serves as an intermediate between tryptophane and nicotinic acid in the mammal remains to be detd.