Chewing ameliorates stress-induced suppression of spatial memory by increasing glucocorticoid receptor expression in the hippocampus
Chewing ameliorates stress-induced suppression of spatial memory by increasing glucocorticoid receptor expression in the hippocampus
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DOI：
10.1016/j.brainres.2012.01.011
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发表时间：
2012-03-29
期刊：
影响因子：
2.9
通讯作者：
Sato, Sadao
中科院分区：
文献类型：
--
作者：
Miyake, Shinjiro;Yoshikawa, Gota;Sato, Sadao
咀嚼改变了下丘脑-垂体-肾上腺轴的功能，并提高了啮齿动物应对压力的能力。鉴于应激对海马区依赖的学习和记忆有负面影响，我们的目的是阐明咀嚼运动是否改善了应激诱导的空间记忆障碍，并伴随着海马糖皮质激素受体表达的增加。采用束缚应激法对雄性SD大鼠进行束缚应激2 h：应激伴咀嚼(SC)组在制动后半段时间内允许咀嚼木棍，而应激非咀嚼(ST)组则不允许这样做。与SC组相比，ST组在Morris水迷宫测试中的表现明显受损。此外，ST组大鼠海马胺1区糖皮质激素受体免疫阳性神经元的数量明显低于对照组和SC组。正常大鼠和SC大鼠在水迷宫成绩和糖皮质激素受体免疫阳性神经元数目方面均无显著差异。免疫组织化学结果与水迷宫实验结果相关。这些结果表明，咀嚼是通过增加海马糖皮质激素受体的表达来应对应激的行为机制。(C)2012爱思唯尔B.V.保留所有权利。
Chewing alters hypothalamic-pituitary-adrenal axis function and improves the ability to cope with stress in rodents. Given that stress negatively influences hippocampus-dependent learning and memory, we aimed to elucidate whether masticatory movements, namely chewing, improve the stress-induced impairment of spatial memory in conjunction with increased hippocampal glucocorticoid receptor expression. Male Sprague-Dawley rats were subjected to restraint stress by immobilization for 2 h: the stress with chewing (SC) group were allowed to chew on a wooden stick during the latter half of the immobilization period, whereas the stress without chewing (ST) group were not allowed to do so. Performance in the Morris water maze test was significantly impaired in the ST group compared with the SC group. Further, the numbers of glucocorticoid receptor immunopositive neurons in the hippocampal comu ammonis 1 region were significantly lower in the ST group than in the control and SC groups. The control and SC rats showed no significant differences in both the water maze performance and the numbers of glucocorticoid receptor-immunopositive neurons. The immunohistochemical finding correlated with the performance in the water maze test These results suggest that chewing is a behavioral mechanism to cope with stress by increasing hippocampal glucocorticoid receptor expression. (C) 2012 Elsevier B.V. All rights reserved.