Clostridium difficile Infection in Children: Current State and Unanswered Questions.
Clostridium difficile Infection in Children: Current State and Unanswered Questions.
复制标题
儿童艰难梭菌感染：现状和未解答的问题。
DOI：
10.1093/jpids/pis071
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发表时间：
2012
影响因子：
3.2
通讯作者：
Sandora,ThomasJ
中科院分区：
文献类型：
--
作者：
Tamma,PranitaD;Sandora,ThomasJ
过去十年中，儿童艰难梭菌感染（CDI）的发病率有所增加。近年来，出现了有关儿科 CDI 的新的有趣数据。社区发病的感染越来越受到人们的重视，即使是在以前没有接受过抗生素治疗的儿童中也是如此。高达 20% 的儿科 CDI 病例是由高毒力菌株引起的。儿童 CDI 的独特危险因素已被确定。诊断测试策略的进步，包括核酸扩增测试的使用，对诊断儿童 CDI 的最佳方法提出了新的问题。新的治疗方案可供 CDI 成年患者使用，这引发了有关在儿童中使用这些药物的问题。有关感染预防和控制措施的最新建议现已发布。我们在这篇综述中总结了儿科 CDI 的最新进展，并强调了未来研究工作中应解决的剩余知识差距。
The incidence ofClostridium difficileinfection (CDI) in children has increased over the past decade. In recent years, new and intriguing data on pediatric CDI have emerged. Community-onset infections are increasingly recognized, even in children who have not previously received antibiotics. A hypervirulent strain is responsible for up to 20% of pediatric CDI cases. Unique risk factors for CDI in children have been identified. Advances in diagnostic testing strategies, including the use of nucleic acid amplification tests, have raised new questions about the optimal approach to diagnosing CDI in children. Novel therapeutic options are available for adult patients with CDI, raising questions about the use of these agents in children. Updated recommendations about infection prevention and control measures are now available. We summarize these recent developments in pediatric CDI in this review and also highlight remaining knowledge gaps that should be addressed in future research efforts.