Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers.
Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers.
复制标题
DOI：
10.1186/1478-811x-9-13
复制
发表时间：
2011-05-15
期刊：
影响因子：
--
通讯作者：
Feller SM
中科院分区：
文献类型：
--
作者：
Ehsanian R;Van Waes C;Feller SM
这是一个深入的回顾奎纳克林的历史，以及它的药代动力学特性，并建立了作为FDA批准的药物的安全性记录。讨论了喹卡林作为抗癌药物的潜在用途，特别是它对核蛋白、花生四烯酸途径和多药耐药的作用，以及它对细胞质中信号蛋白的作用。特别是，奎纳克林在核因子-κB、P53和AKT通路中的作用进行了综述。
This is an in-depth review of the history of quinacrine as well as its pharmacokinetic properties and established record of safety as an FDA-approved drug. The potential uses of quinacrine as an anti-cancer agent are discussed with particular attention to its actions on nuclear proteins, the arachidonic acid pathway, and multi-drug resistance, as well as its actions on signaling proteins in the cytoplasm. In particular, quinacrine's role on the NF-κB, p53, and AKT pathways are summarized.