Diagnosis of lung cancer - Pathology of invasive and preinvasive neoplasia
Diagnosis of lung cancer - Pathology of invasive and preinvasive neoplasia
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DOI：
10.1378/chest.117.4_suppl_1.80s
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发表时间：
2000-04-01
期刊：
影响因子：
9.6
通讯作者：
Franklin, WA
中科院分区：
文献类型：
--
作者：
Franklin, WA
肺癌的组织病理学表现仍然是预后和治疗的重要指导。新修订的世界卫生组织分类保留了旧分类中最广泛的病理学类别，但包括几个修订，包括取消小细胞、中间细胞类型类别;增加大细胞神经内分泌和梭形/巨细胞类别;以及扩大对癌前病变的考虑。随着临床实践和对这些肿瘤的生物学理解的改变，肺癌的组织病理学分类预计将继续改变。应用免疫组织化学检测组织学材料不仅提供了新的援助与传统的组织学分类，但也允许新的方法来细分肿瘤，其全部临床意义尚未实现。神经内分泌标志物表达的意义、对化疗反应的组织学分级以及浸润性癌发生前形态学变化的描述都是了解气道微观细胞变化对临床进展至关重要的领域。
The histopathologic appearance of lung carcinoma remains an important guide to prognosis and treatment. The newly revised World Health Organization classification retains the broadest pathologic categories of the older classification but includes several revisions, including the elimination of the small cell, intermediate cell type category; the addition of large cell neuroendocrine and spindle/giant cell categories; and an extended consideration of preneoplastic lesions. The histopathologic classification of lung cancer is expected to continue to change as clinical practice and biological understanding of these tumors change. The application of immunohistochemical testing to histologic material not only provides new assistance with conventional histologic classification, but also permits new ways to subclassify tumors, the full clinical significance of which is yet to be realized. The significance of expression of neuroendocrine markers, histologic grading of response to chemotherapy, and delineation of morphologic changes preceding the occurrence of invasive carcinoma are all areas where understanding microscopic cellular changes in the airways will be critical for clinical advance.